HCV prevalence and treatment outcomes among drug users in an outpatient center for drug addiction in Northern Italy.

IF 1.1 4区医学 Q4 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annali dell'Istituto superiore di sanita Pub Date : 2023-04-01 DOI:10.4415/ANN_23_02_03

Assunta Lanza, Miriam Olivola, Gianluca Peschi, Natascia Brondino, Pierluigi Politi

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引用次数: 0

Abstract

Introduction: We aimed at evaluating hepatitis C virus (HCV) prevalence and treatment referral outcomes in a large population of drug users in Northern Italy.

Material and methods: Each participant underwent a quick capillary blood test. Positive participants underwent HCV RNA quantification. HCV RNA positive subjects were referred to treatment and evaluated immediately at the end of treatment and at 3 and 6 months after treatment.

Results: Of the 636 participants tested, 244 were positive. Intravenous drug use was more frequent among subjects who tested positive for HCV antibodies (99%). Among subjects who tested positive, 68% were HCV-RNA positive while 32% were negative. Among people referred to treatment, nearly 30% did not show up while 70% completed the treatment with success. Over 99% of people who started direct-acting antiviral agent (DAA) have a sustained response.

Discussion: We observed a significant higher prevalence of HCV positive subjects among people who inject drugs (99%) and we observed a high success rate for HCV treatment engagement.

Conclusions: Rapid testing for HCV represents a potential tool for HCV screening among high-risk groups.

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意大利北部吸毒成瘾门诊中心吸毒者中HCV患病率和治疗结果

前言:我们旨在评估意大利北部大量吸毒者的丙型肝炎病毒(HCV)患病率和治疗转诊结果。材料和方法:每位参与者都进行了快速毛细血管血液检查。阳性参与者进行HCV RNA定量。HCV RNA阳性受试者在治疗结束后以及治疗后3个月和6个月立即接受治疗和评估。结果:在636名参与者中，有244人呈阳性。在HCV抗体检测呈阳性的受试者中，静脉注射药物使用更为频繁(99%)。在检测呈阳性的受试者中，68%为HCV-RNA阳性，32%为阴性。在接受治疗的患者中，近30%的人没有出现，而70%的人成功完成了治疗。超过99%开始使用直接作用抗病毒药物(DAA)的人有持续的反应。讨论:我们观察到注射吸毒者中HCV阳性受试者的患病率明显更高(99%)，我们观察到HCV治疗参与的成功率很高。结论:HCV快速检测是高危人群筛查HCV的潜在工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annali dell'Istituto superiore di sanita PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

3.80

自引率

4.80%

发文量

审稿时长

>12 weeks

期刊介绍： Annali dell’Istituto Superiore di Sanità is a peer reviewed quarterly science journal which publishes research articles in biomedicine, translational research and in many other disciplines of the health sciences. The journal includes the following material: original articles, reviews, commentaries, editorials, brief and technical notes, book reviews. The publication of Monographic Sections has been discontinued. In case you wish to present a small number of coordinated contributions on specific themes concerning priorities in public health, please contact the Editorial office. The journal is in English.