Development and Psychometric Validation of the 27 Item Zarit Caregiver Interview for Alzheimer's Disease (ZCI-AD-27).

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Current Alzheimer research Pub Date : 2023-01-01 DOI:10.2174/1567205020666221230103505

Coen A Bernaards, Kathrin I Fischer, Angela J Rylands, Adam Gater, Chloe Tolley, Steven H Zarit, Claire J Lansdall

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Abstract

Background: Caring for an individual with Alzheimer's disease (AD) is an allencompassing challenge that affects daily life. Assessment of the care partner experience is needed to support the development and evaluation of successful interventions for people with AD and their care partners. We developed the 27-item Zarit Caregiver Interview for Alzheimer's Disease (ZCI-AD-27) to assess the impact of informal caregiving in the context of AD.

Objective: We assessed the psychometric validity of the ZCI-AD-27 in a population of care partners for individuals with moderate AD, and established thresholds for meaningful score change.

Methods: Secondary data were obtained from informal care partners of participants in a clinical trial (NCT01677754). Psychometric analyses were conducted to assess validity, reliability, and responsiveness of the ZCI-AD-27. Anchor-based and distribution-based methods were performed to determine clinically meaningful score change.

Results: The ZCI-AD-27 had a 12-domain factor structure, including a second-order domain termed Humanistic impact that included four key domains (Physical, Emotional, Social, and Daily life) as confirmed by confirmatory factor analysis with the adequate fit. Internal consistency (Cronbach's alpha ranging from 0.66 to 0.93 for domains), convergent validity, and discriminant validity indicated the good performance of the ZCI-AD-27. Known-groups validity analyses showed a greater impact on care partners with increasing disease severity. Responsiveness results demonstrated that the ZCI-AD- 27 is sensitive to change over time and meaningful change analyses indicated a range of meaningful score changes in this population.

Conclusion: The ZCI-AD-27 is a comprehensive, psychometrically valid measure to assess the impact of caring for individuals with moderate AD.

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阿尔茨海默病27项Zarit护理人员访谈(ZCI-AD-27)的编制和心理测量学验证。

背景:照顾阿尔茨海默病(AD)患者是一项影响日常生活的全方位挑战。需要对护理伙伴的经验进行评估，以支持开发和评估针对AD患者及其护理伙伴的成功干预措施。我们开发了一项包含27个项目的Zarit照顾者阿尔茨海默病访谈(ZCI-AD-27)，以评估非正式照顾对阿尔茨海默病的影响。目的:我们评估了ZCI-AD-27在中度AD患者护理伙伴群体中的心理测量效度，并建立了有意义的评分变化阈值。方法:从临床试验(NCT01677754)参与者的非正式护理伙伴处获得次要数据。采用心理测量分析来评估ZCI-AD-27的效度、信度和反应性。采用基于锚定和基于分布的方法来确定有临床意义的评分变化。结果:验证性因子分析证实，ZCI-AD-27具有12个域的因子结构，其中人文影响为二级域，包括身体、情感、社会和日常生活四个关键域。内部一致性(域的Cronbach's alpha在0.66 ~ 0.93之间)、收敛效度和区分效度表明ZCI-AD-27具有良好的性能。已知组效度分析显示，随着疾病严重程度的增加，对护理伙伴的影响更大。响应性结果表明，ZCI-AD- 27对随时间的变化很敏感，有意义的变化分析表明，该人群的评分变化范围有意义。结论:ZCI-AD-27是一种全面的、心理测量学上有效的评估中度AD患者护理影响的测量方法。

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来源期刊

Current Alzheimer research 医学-神经科学

CiteScore

4.00

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.