Anti-F-Actin Antibody Positivity on Indirect Immunofluorescence Assay Following Chinese and Alternative Medicine Therapy: A Case Report.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Mala Mahto, Neha Rai, Soma Dey, Ramesh Kumar
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Abstract

Immunofluorescence on human epithelial type 2 cells is the standard screening assay for the detection of antinuclear antibodies (ANA). Cytoplasmic speckled patterns are a common finding. However, the less commonly reported ones include the cytoplasmic fibrillar patterns on indirect immunofluorescence technique (IIFT). The cytoplasmic fibrillar patterns include the cytoplasmic linear (AC-15), cytoplasmic filamentous (AC-16), and cytoplasmic segmental (AC-17). We report a case of cytoplasmic linear (F-actin) detected through IIFT during ANA screening in a 77-year-old man and later reconfirmed on liver mosaic biochip through IIFT on vascular smooth muscle substrate (VSM-47) without features suggestive of anti-smooth muscle antibody involvement post-complementary and alternative medicine therapy initiation.

Abstract Image

中西医结合替代药物治疗后间接免疫荧光检测抗f - actin抗体阳性1例。
人上皮2型细胞的免疫荧光是检测抗核抗体(ANA)的标准筛选方法。细胞质斑点型是一种常见的发现。然而,较少报道的包括间接免疫荧光技术(IIFT)的细胞质纤维模式。胞质纤维类型包括胞质线状(AC-15)、胞质丝状(AC-16)和胞质节段状(AC-17)。我们报告了一例77岁男性患者,在ANA筛查过程中通过IIFT检测到细胞质线状蛋白(F-actin),随后在肝脏嵌合生物芯片上通过血管平滑肌底物(VSM-47)的IIFT再次证实,在补充和替代药物治疗开始后,没有提示抗平滑肌抗体参与的特征。
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来源期刊
Journal of Laboratory Physicians
Journal of Laboratory Physicians MEDICINE, GENERAL & INTERNAL-
自引率
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发文量
99
审稿时长
31 weeks
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