Longitudinal relationship between the gut microbiota variation and diversity and gut graft-versus-host disease (GVHD) following pediatric allogeneic hematopoietic cell transplantation (HCT) – Case series

IF 4.5 3区医学 Q1 MICROBIOLOGY

International Journal of Medical Microbiology Pub Date : 2023-05-01 DOI:10.1016/j.ijmm.2023.151580

Ashley N. Gray , Nicole H. Tobin , Theodore B. Moore , Fan Li , Grace M. Aldrovandi

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引用次数: 1

Abstract

Allogeneic Hematopoietic Cell Transplantation (HCT) offers children with life-threatening diseases a chance at survival. Complications from graft-versus-host disease (GVHD, Stages 0–4) represent a significant cause of morbidity and mortality which has been recently associated with gut dysbiosis the adult HCT population. Here, our objective was to conduct a prospective, longitudinal cohort study in nine pediatric allogeneic HCT participants by collecting longitudinally post-HCT stool specimens up to 1 year. Stool microbiota analyses showed that allogeneic HCT and antibiotic therapy lead to acute shifts in the diversity of the gut microbiota with those experiencing stages 3–4 gut GVHD having significantly greater microbiota variation over time when compared to control participants (p = 0.007). Pre-HCT microbiota diversity trended towards an inverse relationship with gut microbiota stability over time, however, this did not reach statistical significance (p = 0.05). Future large prospective studies are necessary to elucidate the mechanisms underlying these dynamic changes in the gut microbiota following pediatric allogeneic HCT.

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儿童异基因造血细胞移植（HCT）后肠道微生物群变异和多样性与肠道移植物抗宿主病（GVHD）之间的纵向关系——病例系列

异基因造血细胞移植为患有危及生命的疾病的儿童提供了生存的机会。移植物抗宿主病（GVHD，0-4期）的并发症是发病率和死亡率的重要原因，最近与成年HCT人群的肠道生态失调有关。在此，我们的目的是通过收集HCT后长达1年的纵向粪便样本，对9名儿童异基因HCT参与者进行前瞻性纵向队列研究。粪便微生物群分析表明，异基因HCT和抗生素治疗会导致肠道微生物群多样性的急性变化，与对照组相比，经历3-4期肠道移植物抗宿主病的参与者随着时间的推移，微生物群的变化明显更大（p=0.007）然而，时间并没有达到统计学意义（p=0.05）。未来有必要进行大型前瞻性研究，以阐明儿童异基因HCT后肠道微生物群动态变化的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Medical Microbiology 医学-病毒学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

45 days

期刊介绍： Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.