TIGIT-based immunotherapeutics in lung cancer.

IF 4.1 Q2 IMMUNOLOGY
Akshay J Patel, Gary W Middleton
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引用次数: 0

Abstract

In this review, we explore the biology of the TIGIT checkpoint and its potential as a therapeutic target in lung cancer. We briefly review a highly selected set of clinical trials that have reported or are currently recruiting in non-small cell and small cell lung cancer, a disease transformed by the advent of PD-1/PD-L1 checkpoint blockade immunotherapy. We explore the murine data underlying TIGIT blockade and further explore the reliance of effective anti-TIGIT therapy on DNAM-1(CD226)-positive activated effector CD8+ T cells. The synergism with anti-PD-1 therapy is also explored. Future directions in the realm of overcoming resistance to checkpoint blockade and extending the repertoire of other checkpoints are also briefly explored.

Abstract Image

Abstract Image

基于tigit的肺癌免疫治疗。
在这篇综述中,我们探讨了TIGIT检查点的生物学特性及其作为肺癌治疗靶点的潜力。我们简要回顾了一组经过精心挑选的临床试验,这些试验已经报道或正在招募非小细胞和小细胞肺癌患者,PD-1/PD-L1检查点阻断免疫疗法的出现改变了这种疾病。我们探索了TIGIT阻断的小鼠数据,并进一步探索了有效的抗TIGIT治疗对DNAM-1(CD226)阳性激活效应CD8+ T细胞的依赖。还探讨了与抗pd -1治疗的协同作用。还简要探讨了克服对检查点封锁的抵抗和扩展其他检查点的曲目领域的未来方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
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审稿时长
7 weeks
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