Do antihypertensive medications have an effect on dental implants? A systematic review.

IF 1.7 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Oral and Maxillofacial Surgery-Heidelberg Pub Date : 2024-06-01 Epub Date: 2023-06-17 DOI:10.1007/s10006-023-01167-1

Sunil Kumar Mishra, Nithin Kumar Sonnahalli, Ramesh Chowdhary

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引用次数: 0

Abstract

Purpose: The purpose of this systematic review was to compare the clinical outcomes of dental implants in users of antihypertensive medication with those of nonusers.

Methods: This systematic review followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and was registered in the International Prospective Register of Systematic Reviews under the number CRD42022319336. The electronic databases Medline (PubMed) and Central Cochrane were searched for relevant scientific literature published in English through May 2022. The focused question was, "Do patients taking antihypertensive medications have a similar impact on the clinical outcome and survival of dental implants compared with nonusers?".

Results: A total of 49 articles were found, of which 3 articles were finally selected for a qualitative synthesis. The three studies included 959 patients. In all three studies, the commonly used medication was renin-angiotensin system (RAS) inhibitors. Two studies mentioned implant survival rate, which was 99.4% in antihypertensive medication users and 96.1% in the nonusers. One study found a higher implant stability quotient (ISQ) in patients taking antihypertensive medication (75.7 ± 5.9) compared with patients not taking antihypertensive medication (73.7 ± 8.1).

Conclusions: The limited available evidence showed that patient taking antihypertensive medications had comparable success rate and implant stability to patients not taking medications. The studies included patients taking different antihypertensive medications, so a drug-specific conclusion regarding the clinical outcome of dental implants is not possible. Further studies are needed, including patients taking certain antihypertensive medications, to determine their effects on dental implants.

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抗高血压药物对种植牙有影响吗？系统综述。

目的：本系统综述的目的是比较使用降压药物者与未使用降压药物者种植牙的临床效果：本系统综述遵循《系统综述和元分析首选报告项目》指南，并在国际系统综述前瞻性注册中心注册，注册号为 CRD42022319336。研究人员在 Medline (PubMed) 和 Cochrane 中心电子数据库中检索了截至 2022 年 5 月发表的相关英文科学文献。重点问题是："与不服用高血压药物的患者相比，服用高血压药物的患者对牙科植入物的临床效果和存活率是否有类似的影响？结果：共找到 49 篇文章，最终选择其中 3 篇进行定性综合。这三项研究共纳入 959 名患者。在所有三项研究中，常用药物均为肾素-血管紧张素系统（RAS）抑制剂。两项研究提到了植入物的存活率，使用降压药的患者存活率为 99.4%，未使用降压药的患者存活率为 96.1%。一项研究发现，与未服用降压药的患者（73.7 ± 8.1）相比，服用降压药患者的植入稳定性商数（ISQ）更高（75.7 ± 5.9）：现有的有限证据显示，服用降压药的患者与未服用降压药的患者相比，成功率和植入稳定性相当。这些研究包括了服用不同降压药物的患者，因此无法就种植牙的临床效果得出针对特定药物的结论。还需要进一步的研究，包括服用某些降压药的患者，以确定这些药物对植牙的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral and Maxillofacial Surgery-Heidelberg DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.20

自引率

5.60%

发文量

118

期刊介绍： Oral & Maxillofacial Surgery founded as Mund-, Kiefer- und Gesichtschirurgie is a peer-reviewed online journal. It is designed for clinicians as well as researchers.The quarterly journal offers comprehensive coverage of new techniques, important developments and innovative ideas in oral and maxillofacial surgery and interdisciplinary aspects of cranial, facial and oral diseases and their management. The journal publishes papers of the highest scientific merit and widest possible scope on work in oral and maxillofacial surgery as well as supporting specialties. Practice-oriented articles help improve the methods used in oral and maxillofacial surgery.Every aspect of oral and maxillofacial surgery is fully covered through a range of invited review articles, clinical and research articles, technical notes, abstracts, and case reports. Specific topics are: aesthetic facial surgery, clinical pathology, computer-assisted surgery, congenital and craniofacial deformities, dentoalveolar surgery, head and neck oncology, implant dentistry, oral medicine, orthognathic surgery, reconstructive surgery, skull base surgery, TMJ and trauma.Time-limited reviewing and electronic processing allow to publish articles as fast as possible. Accepted articles are rapidly accessible online.Clinical studies submitted for publication have to include a declaration that they have been approved by an ethical committee according to the World Medical Association Declaration of Helsinki 1964 (last amendment during the 52nd World Medical Association General Assembly, Edinburgh, Scotland, October 2000). Experimental animal studies have to be carried out according to the principles of laboratory animal care (NIH publication No 86-23, revised 1985).