Single nucleotide polymorphisms of enamel formation genes and early childhood caries - systematic review, gene-based, gene cluster and meta-analysis.

Q3 Dentistry

Journal of the Indian Society of Pedodontics and Preventive Dentistry Pub Date : 2023-01-01 DOI:10.4103/jisppd.jisppd_78_23

Aruna Sharma, Sneha S Patil, M S Muthu, Vettriselvi Venkatesan, Richard Kirubakaran, Sivakumar Nuvvula, Selva Arockiam

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引用次数: 0

Abstract

Introduction: Genetic polymorphisms of genes regulating amelogenesis can alter susceptibility to Early Childhood Caries (ECC). This systematic review aims to analyze associations between single-nucleotide polymorphisms of enamel formation genes and ECC.

Methods: Search was conducted across PUBMED, CINAHL, LILACS, SCOPUS, EMBASE, Web of Science, Genome-Wide Association Studies databases from January 2003 to September 2022. This was supplemented by hand search. Totally 7124 articles were identified and 21 articles that satisfied the inclusion criteria proceeded to data extraction. Quality assessment was done using the Q-Genie tool.

Results: Quantitative synthesis revealed that homozygous genotype AA of rs12640848 was significantly higher in children with ECC with an odds ratio of 2.36. Gene-based analysis revealed significant association between six variants of AMBN, four variants of KLK4, two variants of MMP20, and a single variant of each of MMP9 and MMP13 genes and ECC. The Bonferroni corrected-log10 P value of amelogenesis gene Cluster was 2.25 (0.05/88 = 5.6 × 10^-4). Search Tool for Retrieval of Interacting Genes and Proteins plot constructed to comprehend the protein-protein interaction revealed the presence of four functional clusters. Gene function prediction using Multiple Association Network Integration Algorithm revealed that physical interaction between these genes was 69.3%.

Conclusion: Polymorphisms of genes regulating amelogenesis can influence the susceptibility to ECC. AA genotype of rs12640848 may increase the susceptibility to ECC. Gene-based analysis revealed a significant association between multiple polymorphisms of genes regulating amelogenesis and ECC.

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牙釉质形成基因的单核苷酸多态性与儿童早期龋齿的关系——系统综述、基因基础、基因聚类和荟萃分析。

摘要:调节成淀粉性发育的基因的遗传多态性可以改变幼儿龋齿(ECC)的易感性。本系统综述旨在分析釉质形成基因单核苷酸多态性与ECC之间的关系。方法:检索PUBMED、CINAHL、LILACS、SCOPUS、EMBASE、Web of Science、全基因组关联研究数据库，检索时间为2003年1月至2022年9月。这是手工搜索的补充。共鉴定出7124篇文献，其中21篇符合纳入标准的文献进行数据提取。使用Q-Genie工具进行质量评估。结果:定量合成显示，rs12640848纯合基因型AA在ECC患儿中显著升高，优势比为2.36。基于基因的分析显示，AMBN的6个变体、KLK4的4个变体、MMP20的2个变体以及MMP9和MMP13基因的1个变体与ECC之间存在显著相关性。成淀粉基因簇的Bonferroni校正log10 P值为2.25 (0.05/88 = 5.6 × 10-4)。相互作用基因和蛋白质的检索工具构建了了解蛋白质相互作用的图，显示了四个功能簇的存在。利用多关联网络集成算法进行基因功能预测，发现这些基因之间的物理互作率为69.3%。结论:调节成淀粉性发育的基因多态性可影响ECC的易感性。rs12640848的AA基因型可能增加对ECC的易感性。基于基因的分析显示，调节无体发育的基因的多个多态性与ECC之间存在显著关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Indian Society of Pedodontics and Preventive Dentistry Dentistry-Dentistry (all)

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

39 weeks

期刊介绍： Journal of Indian Society of Pedodontics and Preventive Dentistry (ISSN - 0970-4388) is the official organ of Indian Society of Pedodontics and Preventive Dentistry. The journal publishes original articles and case reports pertaining to pediatric and preventive dentistry.