Effectiveness of Fuling () and its extracts against spleen deficiency in rats tonifying spleen.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Pub Date : 2023-06-01 DOI:10.19852/j.cnki.jtcm.2023.03.002

Feng Min, Jia Ziming, Wan Ming, Fan Bolin, Tang Xiaoqiao, Cheng Wenhua, Sun Fanzhong

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引用次数: 1

Abstract

Objective: To observe and explore the effect of Fuling () in alleviating the spleen deficiency symptom pattern (SDSP).

Methods: We established an animal model of SDS in Sprague-Dawley () rats by treating them with deficiency-inducing factors, including irregular feeding and tail clamping. Mice were administered Fuling () and its extracts (raw/cooked powder, aqueous/alcohol extract) by gavage once a day for 21 d. The body weight, rectal temperature, and spleen and thymus organ coefficients were calculated. The levels of motilin (MTL), gastrin (GAS), aquaporin 2 (AQP2), interleukin 2 (IL-2), IL-4, and 5-hydroxytryptamine (5-HT) in the serum and the level of AQP2 in the kidneys were evaluated by enzyme-linked immunosorbent assay.

Results: Fuling () and its extracts did not change the body weight, rectal temperature, and organ coefficients of the spleen and thymus. However, it reduced the levels of MTL and GAS and increased the levels of IL-2 and AQP2. In addition, the levels of IL-4 and 5-HT showed no significant alteration.

Conclusions: These results suggested the crucial function of () in SDSP, especially promoting digestive function and water metabolism.

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茯苓及其提取物对脾虚大鼠的补脾作用。

目的:观察和探讨茯苓对脾虚证型(SDSP)的缓解作用。方法:以Sprague-Dawley()大鼠为模型，采用不规律喂养、夹尾等虚证诱导因素，建立SDS动物模型。小鼠灌胃涪陵()及其提取物(生/熟粉末、水/醇提取物)，每天1次，连续灌胃21 d。计算小鼠体重、直肠温度、脾脏和胸腺器官系数。采用酶联免疫吸附法检测大鼠血清胃动素(MTL)、胃泌素(GAS)、水通道蛋白2 (AQP2)、白细胞介素2 (IL-2)、IL-4、5-羟色胺(5-HT)水平及肾脏AQP2水平。结果:茯苓()及其提取物对大鼠体重、直肠温度及脾脏、胸腺脏器系数无明显影响。而MTL和GAS水平降低，IL-2和AQP2水平升高。此外，IL-4和5-HT水平无明显变化。结论:提示()在SDSP中起重要作用，特别是促进消化功能和水分代谢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

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