Tumor budding as a predictor of disease-free survival in patients with cholangiocarcinoma.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Kyung Bin Kim, Ji Hyun Ahn, Soon Wook Kwon, Su Ji Lee, Yury Lee, Seo Young Park, Ahrong Kim, Kyung Un Choi, Chang Hun Lee, Gi Yeong Huh
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引用次数: 1

Abstract

Background: Tumor budding is considered a prognostic factor in several solid cancer types. However, we lack comprehensive information on the importance of tumor budding in cholangiocarcinoma. Therefore, we aimed to assess the prognostic value of tumor budding in intrahepatic and extrahepatic cholangiocarcinomas and to evaluate its correlations with other clinicopathological parameters. Methods: We monitored 219 patients who underwent surgery for intrahepatic or extrahepatic cholangiocarcinoma at the Pusan National University Hospital between 2012 and 2021. Tumor budding was evaluated using the International Tumor Budding Consensus Conference scoring system. Tumor budding was classified into low (0-4), intermediate (5-9), and high (≥10). For statistical analysis, tumor budding was divided into two groups based on the cut-off value of 10 (lower: 0-9 vs. higher: ≥10). The correlations between clinicopathological parameters were examined using the chi-square and Fisher's exact test. The prognostic values of the variables were analyzed using the log-rank test and Cox regression analysis. Results: Low, intermediate, and high tumor buddings were identified in 135 (61.6%), 63 (28.8), and 21 (9.6%), patients, respectively. Higher tumor budding was related to the presence of lymphatic invasion (p = 0.017), higher tumor grade (p = 0.001), higher N category (p = 0.034). In the univariable and multivariable analyses, higher tumor budding was associated with shorter disease-free survival in 97 (44.3%) patients who underwent R0 resection (p < 0.001 and p = 0.011). Tumor budding did not significantly correlate with disease-specific survival in entire patients. Conclusion: Tumor budding may serve as a prognostic factor for intrahepatic and extrahepatic cholangiocarcinomas treated with R0 resection.

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肿瘤出芽作为胆管癌患者无病生存的预测因子。
背景:肿瘤出芽被认为是几种实体癌类型的预后因素。然而,我们缺乏关于肿瘤萌芽在胆管癌中的重要性的全面信息。因此,我们的目的是评估肿瘤萌芽在肝内和肝外胆管癌中的预后价值,并评估其与其他临床病理参数的相关性。方法:我们监测了2012年至2021年间在釜山国立大学医院接受肝内或肝外胆管癌手术的219例患者。使用国际肿瘤萌芽共识会议评分系统评估肿瘤萌芽。肿瘤出芽分为低(0-4)、中(5-9)、高(≥10)。为进行统计分析,肿瘤出芽按临界值10分为两组(低:0-9,高:≥10)。临床病理参数间的相关性采用卡方检验和Fisher精确检验。采用log-rank检验和Cox回归分析对各变量的预后价值进行分析。结果:135例(61.6%)、63例(28.8%)和21例(9.6%)患者分别有低、中、高肿瘤萌芽。肿瘤出芽率高与淋巴浸润有关(p = 0.017),肿瘤分级高(p = 0.001), N分型高(p = 0.034)。在单变量和多变量分析中,接受R0切除术的97例(44.3%)患者中,较高的肿瘤出芽与较短的无病生存期相关(p < 0.001和p = 0.011)。在所有患者中,肿瘤出芽与疾病特异性生存率无显著相关性。结论:肿瘤出芽可能是R0切除肝内和肝外胆管癌的预后因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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