Radiopharmaceutical for detecting PSMA - positive metastatic colon cancer: Matched-pair comparison of 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI.

IF 0.6 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Omer Aras, Cetin Demirdag, Harikrishna Kommidi, Richard Ting, Haluk B Sayman
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引用次数: 1

Abstract

Prostate-specific membrane antigen (PSMA) - based radiopharmaceuticals are promising for the evaluation of PSMA-positive non-prostate cancers. In this case study, 18F-BF3-Cy3-ACUPA and 68Ga-PSMA positron emission tomography/magnetic resonance imaging (PET/MRI) were compared in a patient with metastatic colon cancer. Both 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI showed biopsy-proven metastatic left external iliac adenopathy, highlighting the feasibility of PSMA uptake in PET/MRI of metastatic nodal disease from colon cancer. Along with imaging evaluation, PSMA-based radiopharmaceuticals may also be used as a surrogate imaging tracer for potential theranostic applications using alpha or beta emitters in the context of PSMA-directed radiopharmaceutical therapy in advanced and progressive colorectal cancer.

Abstract Image

放射性药物检测PSMA阳性转移性结肠癌:18f - bf3 - cy3 - acua与68Ga-PSMA PET/MRI的配对比较
基于前列腺特异性膜抗原(PSMA)的放射性药物在PSMA阳性非前列腺癌的评估中具有广阔的应用前景。在本病例研究中,我们比较了一例转移性结肠癌患者的18f - bf3 - cy3 - acua和68Ga-PSMA正电子发射断层扫描/磁共振成像(PET/MRI)。18f - bf3 - cy3 -针灸和68Ga-PSMA PET/MRI均显示活检证实的转移性左髂外腺病,强调PSMA摄取在结肠癌转移性淋巴结病的PET/MRI中的可行性。随着成像评估,基于psma的放射性药物也可以用作替代成像示踪剂,用于在psma导向的晚期和进展性结直肠癌放射药物治疗中使用α或β发射器的潜在治疗应用。
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来源期刊
NUCLEAR MEDICINE REVIEW
NUCLEAR MEDICINE REVIEW RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.40
自引率
0.00%
发文量
53
审稿时长
24 weeks
期刊介绍: Written in English, NMR is a biannual international periodical of scientific and educational profile. It is a journal of Bulgarian, Czech, Hungarian, Macedonian, Polish, Romanian, Russian, Slovak, Ukrainian and Yugoslav Societies of Nuclear Medicine. The periodical focuses on all nuclear medicine topics (diagnostics as well as therapy), and presents original experimental scientific papers, reviews, case studies, letters also news about symposia and congresses. NMR is indexed at Index Copernicus (7.41), Scopus, EMBASE, Index Medicus/Medline, Ministry of Education 2007 (4 pts.).
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