Adverse Drug Reactions in Psychiatry Outpatient Department of a Tertiary Care Hospital in Western Uttar Pradesh: An Observational Study.

IF 0.8 Q4 PHARMACOLOGY & PHARMACY

Journal of Research in Pharmacy Practice Pub Date : 2022-07-01 DOI:10.4103/jrpp.jrpp_51_22

Jaspreet Kaur Sidhu, Kiran Jakhar, Deepti Chopra, Aditi Dhote, Vishakha Babber, Mohammad Shadman, C D Tripathi

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引用次数: 0

Abstract

Objective: Psychiatric disorders are chronic in nature which require medications for a long duration. These medications have been associated with many adverse events. Failure to recognize an adverse drug reaction (ADR) exposes the patient to continuing risk of ADR, leading to a significant impact on patient's quality of life. Thus, the present study carried out to identify the pattern of ADRs reported due to psychotropic medication.

Methods: This was a cross-sectional study conducted to analyze ADRs reported from the psychiatry department of a tertiary care teaching hospital from October 2021 to March 2022.

Findings: A total of 137 ADRs were identified from 102 patients. Majority of the ADRs were reported from antidepressants, with paroxetine being the leading offending drug. The central nervous system was most commonly affected, and dizziness (13.13%) was the most common ADR noted. On causality assessment, 97 ADRs (70.8%) were of "possible" type. Almost half of the patients with ADRs (47.5%) recovered spontaneously. No ADR encountered turned out to be fatal.

Conclusion: The present study revealed that the majority of ADRs reported from psychiatry OPD were mild in nature. We reinforce the identification of ADR is crucial in the hospital setting process as it gives an insight into the risk-benefit ratio for rational use of the drug.

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西北方邦某三级医院精神科门诊药物不良反应:一项观察性研究。

目的:精神疾病是慢性的，需要长期的药物治疗。这些药物与许多不良事件有关。未能识别药物不良反应(ADR)会使患者面临持续的ADR风险，从而对患者的生活质量产生重大影响。因此，本研究旨在确定精神药物引起的不良反应报告的模式。方法:这是一项横断面研究，分析2021年10月至2022年3月一家三级护理教学医院精神科报告的不良反应。结果:102例患者共发现137例不良反应。据报道，大多数不良反应来自抗抑郁药，帕罗西汀是主要的致病药物。最常见的不良反应是中枢神经系统，头晕(13.13%)是最常见的不良反应。在因果关系评价中，97例adr为“可能”型，占70.8%。几乎一半的不良反应患者(47.5%)自发恢复。没有出现致命的不良反应。结论:本研究显示精神科门诊报告的大多数不良反应是轻微的。我们强调，在医院设置过程中，ADR的识别是至关重要的，因为它提供了对合理使用药物的风险-收益比的洞察。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Research in Pharmacy Practice PHARMACOLOGY & PHARMACY-

自引率

0.00%

发文量

审稿时长

21 weeks

期刊介绍： The main focus of the journal will be on evidence-based drug-related medical researches (with clinical pharmacists’ intervention or documentation), particularly in the Eastern Mediterranean region. However, a wide range of closely related issues will be also covered. These will include clinical studies in the field of pharmaceutical care, reporting adverse drug reactions and human medical toxicology, pharmaco-epidemiology and toxico-epidemiology (poisoning epidemiology), social aspects of pharmacy practice, pharmacy education and economic evaluations of treatment protocols (e.g. cost-effectiveness studies). Local reports of medication utilization studies at hospital or pharmacy levels will only be considered for peer-review process only if they have a new and useful message for the international pharmacy practice professionals and readers.