Transethosomes: A Promising Challenge for Topical Delivery Short Title: Transethosomes for Topical Delivery.

IF 1.7 Q3 PHARMACOLOGY & PHARMACY
Drug Research Pub Date : 2023-04-01 DOI:10.1055/a-1974-9078
Mohammad Adnan, Md Faheem Haider, Nazish Naseem, Tanweer Haider
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引用次数: 3

Abstract

Skin provides an excellent barrier to molecular transport, as the stratum corneum is the most formidable barrier to the passage of most pharmaceuticals. Various attempts have been made to improve drug administration into the body through intact skin. Though very few routes are as attractive as the topical route, drug transport through the skin is challenging. To overcome the challenges, researchers have found a system in which the drug is encapsulated into the vesicle, penetrating deeper into the skin to hit the target site. Vesicular systems like transethosome, an ultra- deformable vesicle (UDV), tend to accumulate in the skin layers. Since transethosomes have small particle size and can easily alter the shape of vesicles compared to other vesicular systems, they can penetrate through the layers of skin. Hence, the drug encapsulated into transethosomes can easily reach the target site. Transethosomes consist of ethanol and phospholipids along with an edge activator. Ethanol and edge activator help to enhance the skin permeation of transethosomes. Various methods of preparation of transethosomes, comparison of transethosomes with other lipid vesicles, characterization of transethosomes, and application of transethosomes have been covered in this review. Transethosomes can deliver a different variety of drugs, such as anticancer, corticosteroids, proteins and peptides, analgesics.

转运体:局部递送的一个有希望的挑战简短标题:局部递送的转运体。
皮肤为分子运输提供了一个极好的屏障,因为角质层是大多数药物通过的最强大的屏障。人们已经进行了各种尝试,以改善通过完整皮肤进入体内的药物给药。虽然很少有途径像局部途径一样有吸引力,但药物通过皮肤的运输是具有挑战性的。为了克服这些挑战,研究人员发现了一种系统,该系统将药物包裹在囊泡中,深入皮肤以击中目标部位。囊泡系统,如转酶体,一种超变形囊泡(UDV),倾向于积聚在皮肤层。与其他囊泡系统相比,transsesomal颗粒小,容易改变囊泡的形状,因此它们可以穿透皮肤的各个层。因此,包裹在转运体中的药物可以很容易地到达目标部位。转酶体由乙醇和磷脂以及边缘激活剂组成。乙醇和边缘活化剂有助于提高转运体的皮肤渗透。本文综述了转酶体的各种制备方法、转酶体与其他脂质囊泡的比较、转酶体的特性以及转酶体的应用。转运体可以运送不同种类的药物,如抗癌、皮质类固醇、蛋白质和多肽、镇痛药。
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来源期刊
Drug Research
Drug Research PHARMACOLOGY & PHARMACY-
CiteScore
3.50
自引率
0.00%
发文量
67
期刊介绍: Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.
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