Antihypertensive Effect of Euphorbia cheiradenia in Rats.

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2023-01-01 DOI:10.2174/1871525721666230118154023

Smail Amthaghri, Ayoub Amssayef, Miloudia Slaoui, Mohamed Eddouks

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Abstract

Aims: The study aimed to investigate the effect of Euphorbia cheiradenia on blood pressure.

Background: Euphorbia cheiradenia is a medicinal plant with several medicinal properties.

Objective: This study aimed to study the vasorelaxant and antihypertensive capacity of the aqueous extract of Euphorbia cheiradenia (E. cheiradenia), and to evaluate its effect on angiotensinconverting enzyme 2 (ACE2).

Methods: The antihypertensive ability of aerial parts of the aqueous extract of E. cheiradenia (AEEC) was investigated in L-NAME-induced hypertensive rats, and its vasorelaxant effect was performed on the isolated thoracic rat aorta. In addition, the possible inhibitory effect of AEEC on ACE2 was also studied.

Results: AEEC lowered blood pressure parameters in hypertensive rats. The study of the vasorelaxant activity revealed that AEEC partially relaxed the aortic rings through activation of the KATP channel and inhibition of the β-adrenergic pathway. Whereas pretreatment of aortic rings with nifedipine, indomethacin, L-NAME, and methylene blue did not attenuate AEEC-induced vasorelaxation. However, AEEC did not affect ACE2 in isolated rat aortas.

Conclusion: The study showed that aqueous E. cheiradenia extract exhibits significant antihypertensive activity in hypertensive rats.

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大戟对大鼠的降压作用。

目的:研究大戟对血压的影响。背景:大戟是一种具有多种药用特性的药用植物。目的:研究大戟水提物的血管舒张和降压作用，并评价其对血管紧张素转换酶2 (ACE2)的影响。方法:采用l - name诱导的高血压大鼠实验，观察海戟水提物空中部位的降压作用，并对离体大鼠胸主动脉进行血管舒张实验。此外，还研究了AEEC对ACE2可能的抑制作用。结果:AEEC降低高血压大鼠血压指标。血管松弛活性的研究表明，AEEC通过激活KATP通道和抑制β-肾上腺素能通路部分放松主动脉环。然而，用硝苯地平、吲哚美辛、L-NAME和亚甲基蓝预处理主动脉环并没有减弱aeec诱导的血管松弛。然而，AEEC不影响离体大鼠主动脉的ACE2。结论:研究表明，水提物对高血压大鼠具有明显的降压作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.