Progress of tissue adhesives based on proteins and synthetic polymers.

IF 11.3 1区 医学 Q1 Medicine
Gi-Yeon Han, Soo-Kyung Hwang, Ki-Hyun Cho, Hyun-Joong Kim, Chong-Su Cho
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引用次数: 4

Abstract

In recent years, polymer-based tissue adhesives (TAs) have been developed as an alternative to sutures to close and seal incisions or wounds owing to their ease of use, rapid application time, low cost, and minimal tissue damage. Although significant research is being conducted to develop new TAs with improved performances using different strategies, the applications of TAs are limited by several factors, such as weak adhesion strength and poor mechanical properties. Therefore, the next-generation advanced TAs with biomimetic and multifunctional properties should be developed. Herein, we review the requirements, adhesive performances, characteristics, adhesive mechanisms, applications, commercial products, and advantages and disadvantages of proteins- and synthetic polymer-based TAs. Furthermore, future perspectives in the field of TA-based research have been discussed.

Abstract Image

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基于蛋白质和合成聚合物的组织粘接剂的研究进展。
近年来,聚合物基组织粘接剂(TAs)因其易于使用、应用时间短、成本低和组织损伤小而成为缝合和密封切口或伤口的替代方法。尽管人们正在进行大量研究,以开发使用不同策略改善性能的新型TAs,但TAs的应用受到几个因素的限制,例如粘附强度弱和机械性能差。因此,应该开发具有仿生和多功能特性的下一代高级TAs。本文综述了蛋白质基和合成聚合物基TAs的要求、粘合性能、特性、粘合机理、应用、商业产品以及优缺点。最后,对未来的研究方向进行了展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomaterials Research
Biomaterials Research Medicine-Medicine (miscellaneous)
CiteScore
10.20
自引率
3.50%
发文量
63
审稿时长
30 days
期刊介绍: Biomaterials Research, the official journal of the Korean Society for Biomaterials, is an open-access interdisciplinary publication that focuses on all aspects of biomaterials research. The journal covers a wide range of topics including novel biomaterials, advanced techniques for biomaterial synthesis and fabrication, and their application in biomedical fields. Specific areas of interest include functional biomaterials, drug and gene delivery systems, tissue engineering, nanomedicine, nano/micro-biotechnology, bio-imaging, regenerative medicine, medical devices, 3D printing, and stem cell research. By exploring these research areas, Biomaterials Research aims to provide valuable insights and promote advancements in the biomaterials field.
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