Risk Factors for Sarcopenia in Thai Patients with Rheumatoid Arthritis.

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Discovery medicine Pub Date : 2023-06-01 DOI:10.24976/Discov.Med.202335176.44

Wanruchada Katchamart, Suppavich Kieattisaksopon, Pongthorn Narongroeknawin, Weerasak Muangpaisan, Narittaya Varothai

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引用次数: 0

Abstract

Background: Sarcopenia is a common condition that can occur in people with chronic inflammatory diseases, including rheumatoid arthritis (RA). The aim of this study was to determine the prevalence and factors associated with this condition in patients with RA.

Methods: This prospective cross-sectional study was conducted on 182 adult patients with RA. They were diagnosed with sarcopenia using the Asian Working Group's 2019 update on sarcopenia diagnosis. The body composition was estimated using a body impedance analyzer. Physical performance and muscle strength were evaluated with six-meter walk test and hand grip dynamometer, respectively. The Disease Activity Score (DAS) 28 and the Health Assessment Questionnaire (HAQ) were used to assess disease activity and functional status, respectively.

Results: The majority (87.4%) were female with a mean age (SD) of 59.2 (10.2) years. They had been suffering from RA for a long time (median disease duration [Interquartile range (IQR)] 11 [6-16] years) and had mildly active disease [mean DAS28 (SD) 2.61 (0.83)] with slightly functional disability [median HAQ (IQR) 0.34 (0-0.65)]. Of these, 26.4% had sarcopenia. Advanced age [relative risk (RR) 1.07 (95% confidence interval (CI) 1.02-1.11), p = 0.002], low body mass index (BMI) [RR (95% CI) 0.81 (0.72-0.90), p < 0.001], high disease activity [RR (95% CI) 1.64 (1.22-2.12), p = 0.045], and depression [RR (95% CI) 1.18 (1.01-1.37), p = 0.04] were independently associated with sarcopenia.

Conclusions: Sarcopenia was found to be common in Thai RA, and its independent risk factors are age, disease activity, BMI, and depression. Well-controlled disease activity may be beneficial for preventing or minimizing sarcopenia and improving patient outcomes.

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泰国类风湿性关节炎患者肌肉减少的危险因素

背景:骨骼肌减少症是一种常见病，可发生在慢性炎症性疾病患者，包括类风湿关节炎(RA)。本研究的目的是确定RA患者的患病率及其相关因素。方法:对182例成年RA患者进行前瞻性横断面研究。根据亚洲工作组2019年更新的肌肉减少症诊断，他们被诊断为肌肉减少症。使用身体阻抗分析仪估计身体成分。分别用6米步行测试和握力计评估身体性能和肌肉力量。疾病活动性评分(DAS) 28和健康评估问卷(HAQ)分别用于评估疾病活动性和功能状态。结果:女性居多(87.4%)，平均年龄59.2(10.2)岁。他们长期患有类风湿性关节炎(中位病程[四分位间距(IQR)] 11[6-16]年)，病情轻度活动性[平均DAS28 (SD) 2.61(0.83)]，伴有轻度功能障碍[中位HAQ (IQR) 0.34(0-0.65)]。其中，26.4%患有肌肉减少症。高龄[相对危险度(RR) 1.07(95%可信区间(CI) 1.02-1.11)， p = 0.002]、低体重指数(BMI) [RR (95% CI) 0.81 (0.72-0.90)， p < 0.001]、高疾病活动性[RR (95% CI) 1.64 (1.22-2.12)， p = 0.045]、抑郁[RR (95% CI) 1.18 (1.01-1.37)， p = 0.04]与肌肉减少症独立相关。结论:肌肉减少症在泰国类风湿性关节炎中很常见，其独立危险因素为年龄、疾病活动度、BMI和抑郁。控制良好的疾病活动可能有利于预防或减少肌肉减少症和改善患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Discovery medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Discovery Medicine publishes novel, provocative ideas and research findings that challenge conventional notions about disease mechanisms, diagnosis, treatment, or any of the life sciences subjects. It publishes cutting-edge, reliable, and authoritative information in all branches of life sciences but primarily in the following areas: Novel therapies and diagnostics (approved or experimental); innovative ideas, research technologies, and translational research that will give rise to the next generation of new drugs and therapies; breakthrough understanding of mechanism of disease, biology, and physiology; and commercialization of biomedical discoveries pertaining to the development of new drugs, therapies, medical devices, and research technology.