Autoantibodies, clinical phenotypes and quality of life in Lebanese patients with myasthenia gravis.

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Jihan Baalbaki, Mohammad Agha, Nisrin Jaafar, Bassem Yamout, Salim Moussa
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Abstract

Myasthenia gravis (MG) is a rare autoimmune disease that affects the neuromuscular junction. It is characterized by the production of heterogeneous autoantibodies that bind to the neuromuscular junction and alter neural transmission. Recently, more attention was given to MG-related antibodies and their clinical influence. In Lebanon, studies about MG are very rare. To date, there is still no research on the different autoantibodies developed by Lebanese MG patients. We conducted a study aimed at detecting the prevalence of different antibodies in a group of seventeen Lebanese patients with MG, and exploring their associations with clinical phenotypes and quality of life (QOL). MG antibody test in Lebanon is restricted only to two antibodies: acetylcholine receptor (anti-AChR) and muscle-specific kinase (anti-MUSK) antibodies. Results showed that 70.6% of patients were anti-AChR positive and all of them were anti-MUSK negative. Association between MG serological profiles, clinical outcomes and QOL was not significant. Together, current findings suggest that anti-MUSK antibody is not common and difference in antibody profile may not change the clinical phenotypes and QOL of MG Lebanese patients. In the future, it is recommended to check also for autoantibodies other than anti-AChR and anti-MUSK, which may reveal new antibody profiles and possible associations with clinical outcomes.

黎巴嫩重症肌无力患者的自身抗体、临床表型和生活质量。
重症肌无力(MG)是一种罕见的自身免疫性疾病,影响神经肌肉交界处。其特点是产生异质自身抗体,结合神经肌肉连接处并改变神经传递。近年来,mg相关抗体及其临床影响受到越来越多的关注。在黎巴嫩,关于MG的研究非常少。到目前为止,还没有关于黎巴嫩MG患者产生的不同自身抗体的研究。我们进行了一项研究,旨在检测17名黎巴嫩MG患者中不同抗体的患病率,并探讨其与临床表型和生活质量(QOL)的关系。黎巴嫩的MG抗体检测仅限于两种抗体:乙酰胆碱受体(抗achr)和肌肉特异性激酶(抗musk)抗体。结果:70.6%的患者抗achr阳性,抗musk均阴性。MG血清学特征、临床结果与生活质量之间无显著相关性。总之,目前的研究结果表明,抗musk抗体并不常见,抗体谱的差异可能不会改变MG黎巴嫩患者的临床表型和生活质量。在未来,建议还检查抗achr和抗musk以外的自身抗体,这可能会揭示新的抗体谱,并可能与临床结果相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Intractable & rare diseases research
Intractable & rare diseases research MEDICINE, GENERAL & INTERNAL-
CiteScore
2.10
自引率
0.00%
发文量
29
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