Safiya Fatima Khan, Bhavya Shetty, Ibrahim Fazal, Asim Mustafa Khan, Faheem Muzaffar Mir, Muhamood Moothedath, V J Reshma, Muhaseena Muhamood
{"title":"Licorice as a herbal extract in periodontal therapy.","authors":"Safiya Fatima Khan, Bhavya Shetty, Ibrahim Fazal, Asim Mustafa Khan, Faheem Muzaffar Mir, Muhamood Moothedath, V J Reshma, Muhaseena Muhamood","doi":"10.33393/dti.2023.2583","DOIUrl":null,"url":null,"abstract":"<p><p>Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice (<i>Glycyrrhiza glabra</i>) is a perennial herb with substantial medicinal value. Licorice extract is derived from dried, unpeeled stolons and roots of <i>Glycyrrhiza uralensis</i> and <i>G. glabra</i>. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivatives in periodontal therapy. Literature review and clinical trials evaluating the effect of licorice on periodontopathogens and periodontal disease are included in this article.</p>","PeriodicalId":11326,"journal":{"name":"Drug Target Insights","volume":null,"pages":null},"PeriodicalIF":2.0000,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b1/86/dti-17-70.PMC10243202.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug Target Insights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33393/dti.2023.2583","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Periodontal disease is caused by specific pathogens which results in inflammation of the tooth-supporting structures and subsequently causes the continued breakdown of alveolar bone and periodontal ligament. Licorice (Glycyrrhiza glabra) is a perennial herb with substantial medicinal value. Licorice extract is derived from dried, unpeeled stolons and roots of Glycyrrhiza uralensis and G. glabra. The bioactive ingredients in licorice extract such as glycyrrhizin, licoricidin, glabridin, licochalcone A, and licorisoflavan A have anti-inflammatory, antimicrobial, and anti-adherence effects that are beneficial against periodontal disease. Since periodontal disease has a complex etiology that includes the host response and microorganisms, licorice phytochemicals offer a therapeutic advantage due to their dual functionality. The aim of this review was to enumerate the bioactive compounds present in herbal licorice extract and to elucidate the beneficial effects of licorice and its derivatives in periodontal therapy. Literature review and clinical trials evaluating the effect of licorice on periodontopathogens and periodontal disease are included in this article.
牙周病由特定的病原体引起,导致牙齿支撑结构发炎,继而引起牙槽骨和牙周韧带的持续破坏。甘草(Glycyrrhiza glabra)是一种多年生草本植物,具有很高的药用价值。甘草提取物取自甘草和炙甘草未剥皮的干燥匍匐茎和根。甘草提取物中的生物活性成分,如甘草苷、甘草甜素、甘草甜素、甘草查耳酮 A 和甘草异黄酮 A,具有抗炎、抗菌和抗粘连作用,对牙周病有益。由于牙周病的病因复杂,包括宿主反应和微生物,甘草植物化学物质因其双重功能而具有治疗优势。本综述旨在列举草本甘草提取物中的生物活性化合物,并阐明甘草及其衍生物在牙周治疗中的有益作用。本文包括文献综述和评估甘草对牙周病原体和牙周疾病影响的临床试验。