Biotransformation novel advances - 2021 year in review.

IF 3.4 2区医学 Q2 PHARMACOLOGY & PHARMACY

Drug Metabolism Reviews Pub Date : 2022-08-01 DOI:10.1080/03602532.2022.2097253

S Cyrus Khojasteh, Upendra A Argikar, Sungjoon Cho, Rachel Crouch, Carley J S Heck, Kevin M Johnson, Amit S Kalgutkar, Lloyd King, Hlaing Holly Maw, Herana Kamal Seneviratne, Shuai Wang, Cong Wei, Donglu Zhang, Klarissa D Jackson

引用次数: 3

Abstract

Biotransformation field is constantly evolving with new molecular structures and discoveries of metabolic pathways that impact efficacy and safety. Recent review by Kramlinger et al. (2022) nicely captures the future (and the past) of highly impactful science of biotransformation (see the first article). Based on the selected articles, this review was categorized into three sections: (1) new modalities biotransformation, (2) drug discovery biotransformation, and (3) drug development biotransformation (Table 1).

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生物转化新进展- 2021年回顾。

随着新的分子结构和代谢途径的发现，生物转化领域不断发展，影响着生物转化的有效性和安全性。Kramlinger等人(2022)最近的一篇综述很好地捕捉到了具有高度影响力的生物转化科学的未来(和过去)(见第一篇文章)。根据所选文章，本文分为三个部分:(1)新模式生物转化，(2)药物发现生物转化，(3)药物开发生物转化(表1)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Metabolism Reviews 医学-药学

CiteScore

11.10

自引率

1.70%

发文量

审稿时长

1 months

期刊介绍： Drug Metabolism Reviews consistently provides critically needed reviews of an impressive array of drug metabolism research-covering established, new, and potential drugs; environmentally toxic chemicals; absorption; metabolism and excretion; and enzymology of all living species. Additionally, the journal offers new hypotheses of interest to diverse groups of medical professionals including pharmacologists, toxicologists, chemists, microbiologists, pharmacokineticists, immunologists, mass spectroscopists, as well as enzymologists working in xenobiotic biotransformation.