High trophinin-associated protein expression predicts good survival in acute myeloid leukemia with normal cytogenetics.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Biomarkers Pub Date : 2023-01-01 DOI:10.3233/CBM-210042

Xue He, Jing Hu, Changjian Yan, Xiaoni Liu, Yali Zhao, Ping Yang, Jing Wang, Shaoxiang Li, Wei Zhang, Gehong Dong, Weilong Zhang, Hongmei Jing

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引用次数: 1

Abstract

Background: Nearly half of adult acute myeloid leukemia (AML) patients were classified into cytogenetic normal acute myeloid leukemia (CN-AML). The expression level of Trophinin associated protein (TROAP) was proven to be associated with the prognosis of several cancers, but it is still unclear in the prognosis of patients with CN-AML.

Methods: We integrated CN-AML patient samples from 4 datasets to analyze the relationship between TROAP expression and the survival of CN-AML. In addition, we investigated 92 AML patients of The Cancer Genome Atlas (TCGA) database to analyze the relationship between TROAP expression and the survival of AML patients received chemotherapy. We investigated the relationship between the expression of TROAP and drug sensitivity in AML cell lines.

Results: CN-AML patients with high TROAP expression were related to good event-free survival (EFS) and overall survival (OS). In AML patients received chemotherapy, high TROAP expression was associated with good survival prognosis. Additionally, the expression of TROAP gene in leukemia stem cells (LSC) + group was lower. Among multiple drugs, the lower the expression of TROAP, the lower the IC50.

Conclusion: TROAP could serve as an independent predictor of CN-AML patients and could act as a potential biomarker for the prognosis of CN-AML. TROAP expression levels were closely correlated with the drug sensitivity of multiple drugs.

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在细胞遗传学正常的急性髓系白血病中，高营养蛋白相关蛋白的表达预示着良好的生存率。

背景:近一半的成人急性髓性白血病(AML)患者可归为细胞遗传学正常的急性髓性白血病(CN-AML)。Trophinin associated protein (TROAP)的表达水平已被证实与几种癌症的预后相关，但在CN-AML患者的预后中仍不清楚。方法:我们整合了来自4个数据集的CN-AML患者样本，分析TROAP表达与CN-AML生存之间的关系。此外，我们调查了92例癌症基因组图谱(TCGA)数据库中的AML患者，分析TROAP表达与化疗后AML患者生存的关系。我们研究了AML细胞系中TROAP的表达与药物敏感性之间的关系。结果:TROAP高表达的CN-AML患者具有良好的无事件生存期(EFS)和总生存期(OS)。在接受化疗的AML患者中，高TROAP表达与良好的生存预后相关。此外，TROAP基因在白血病干细胞(LSC) +组表达较低。在多种药物中，TROAP表达越低，IC50越低。结论:TROAP可作为CN-AML患者的独立预测因子，并可作为CN-AML预后的潜在生物标志物。TROAP表达水平与多种药物的药物敏感性密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Biomarkers ONCOLOGY-

CiteScore

5.20

自引率

3.20%

发文量

195

审稿时长

3 months

期刊介绍： Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.