Predictors of COVID-19 severity among pregnant patients.

IF 3.1 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Marcin Januszewski, Laura Ziuzia-Januszewska, Alicja A Jakimiuk, Tomasz Oleksik, Marek Pokulniewicz, Waldemar Wierzba, Krzysztof Kozlowski, Artur J Jakimiuk
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引用次数: 2

Abstract

Coronavirus disease 2019 (COVID-19) was declared a pandemic and has spread around the globe, unsparingly affecting vulnerable populations. Effective prevention measures for pregnant women, who are particularly affected, include early identification of those patients at risk of developing in-hospital complications, and the continuous improvement of maternal-fetal treatment strategies to ensure the efficient use of health resources. The objective of our retrospective study was to determine which patient biomarkers on hospital admission correlate with disease severity as measured by disease course classification, the need for oxygen supplementation and higher demand for oxygen, the need for mechanical ventilation, intensive care unit admission, and length of hospital stay. Analysis of 52 PCR SARS-CoV-2 positive pregnant women revealed that the median date of hospital admission was the 30th gestational week, with dyspnoea, cough, and fever as the leading symptoms. The presence of diabetes and hypertension predisposed pregnant women to the severe course of illness. Lung involvement shown by CT scans on admission correlated with the greater clinical severity. The main laboratory predictors of disease progression were lymphocytopenia, hypocalcemia, low total cholesterol, low total protein levels, and high serum levels of C-reactive protein, ferritin, interleukin-6, glucose, lactate dehydrogenase, procalcitonin, and troponin I. Further research with a larger cohort of pregnant women is needed to determine the utility of these results for everyday practice.

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妊娠患者COVID-19严重程度的预测因素
2019冠状病毒病(COVID-19)被宣布为大流行,并已在全球蔓延,对弱势群体造成了无情的影响。对特别受影响的孕妇采取有效的预防措施,包括及早发现有院内并发症风险的病人,并不断改进母婴治疗战略,确保有效利用卫生资源。我们回顾性研究的目的是确定入院时患者的哪些生物标志物与疾病严重程度相关,这些疾病严重程度由病程分类、需要补充氧气和更高的氧气需求、需要机械通气、重症监护病房入住和住院时间来衡量。52例PCR SARS-CoV-2阳性孕妇入院时间中位数为妊娠第30周,以呼吸困难、咳嗽、发热为主要症状。糖尿病和高血压的存在使孕妇易患严重的疾病。入院时CT扫描显示肺部受累与临床严重程度相关。疾病进展的主要实验室预测指标为淋巴细胞减少症、低钙血症、低总胆固醇、低总蛋白水平和高血清c反应蛋白、铁蛋白、白细胞介素-6、葡萄糖、乳酸脱氢酶、降钙素原和肌钙蛋白i。需要对更大的孕妇队列进行进一步研究,以确定这些结果在日常实践中的实用性。
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来源期刊
Bosnian journal of basic medical sciences
Bosnian journal of basic medical sciences 医学-医学:研究与实验
CiteScore
7.40
自引率
5.90%
发文量
98
审稿时长
35 days
期刊介绍: The Bosnian Journal of Basic Medical Sciences (BJBMS) is an international, English-language, peer reviewed journal, publishing original articles from different disciplines of basic medical sciences. BJBMS welcomes original research and comprehensive reviews as well as short research communications in the field of biochemistry, genetics, immunology, microbiology, pathology, pharmacology, pharmaceutical sciences and physiology.
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