Optical Imaging of Epigenetic Modifications in Cancer: A Systematic Review.

IF 3.7 Q2 GENETICS & HEREDITY

Phenomics (Cham, Switzerland) Pub Date : 2022-04-01 DOI:10.1007/s43657-021-00041-y

Yang Du, Pei Zhang, Wei Liu, Jie Tian

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引用次数: 2

Abstract

Increasing evidence has demonstrated that abnormal epigenetic modifications are strongly related to cancer initiation. Thus, sensitive and specific detection of epigenetic modifications could markedly improve biological investigations and cancer precision medicine. A rapid development of molecular imaging approaches for the diagnosis and prognosis of cancer has been observed during the past few years. Various biomarkers unique to epigenetic modifications and targeted imaging probes have been characterized and used to discriminate cancer from healthy tissues, as well as evaluate therapeutic responses. In this study, we summarize the latest studies associated with optical molecular imaging of epigenetic modification targets, such as those involving DNA methylation, histone modification, noncoding RNA regulation, and chromosome remodeling, and further review their clinical application on cancer diagnosis and treatment. Lastly, we further propose the future directions for precision imaging of epigenetic modification in cancer. Supported by promising clinical and preclinical studies associated with optical molecular imaging technology and epigenetic drugs, the central role of epigenetics in cancer should be increasingly recognized and accepted.

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癌症表观遗传修饰的光学成像:系统综述。

越来越多的证据表明，异常的表观遗传修饰与癌症的发生密切相关。因此，表观遗传修饰的敏感和特异性检测可以显著提高生物学研究和癌症精准医学。在过去的几年里，分子成像方法在癌症的诊断和预后方面有了迅速的发展。表观遗传修饰和靶向成像探针所特有的各种生物标志物已被表征并用于区分癌症和健康组织，以及评估治疗反应。本文综述了近年来表观遗传修饰靶点的光学分子成像研究进展，包括DNA甲基化、组蛋白修饰、非编码RNA调控、染色体重塑等方面的研究进展，并对其在肿瘤诊断和治疗中的临床应用进行了综述。最后，提出了肿瘤表观遗传修饰精准成像的发展方向。在光学分子成像技术和表观遗传学药物等临床和临床前研究的支持下，表观遗传学在癌症中的核心作用应得到越来越多的认识和接受。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Phenomics (Cham, Switzerland)

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