A biomedical open knowledge network harnesses the power of AI to understand deep human biology

IF 2.5 4区计算机科学 Q3 COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE

Ai Magazine Pub Date : 2022-03-31 DOI:10.1002/aaai.12037

Sergio E. Baranzini, Katy Börner, John Morris, Charlotte A. Nelson, Karthik Soman, Erica Schleimer, Michael Keiser, Mark Musen, Roger Pearce, Tahsin Reza, Brett Smith, Bruce W. Herr II, Boris Oskotsky, Angela Rizk-Jackson, Katherine P. Rankin, Stephan J. Sanders, Riley Bove, Peter W. Rose, Sharat Israni, Sui Huang

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引用次数: 0

Abstract

Knowledge representation and reasoning (KR&R) has been successfully implemented in many fields to enable computers to solve complex problems with AI methods. However, its application to biomedicine has been lagging in part due to the daunting complexity of molecular and cellular pathways that govern human physiology and pathology. In this article, we describe concrete uses of Scalable PrecisiOn Medicine Knowledge Engine (SPOKE), an open knowledge network that connects curated information from thirty-seven specialized and human-curated databases into a single property graph, with 3 million nodes and 15 million edges to date. Applications discussed in this article include drug discovery, COVID-19 research and chronic disease diagnosis, and management.

Abstract Image

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生物医学开放知识网络利用人工智能的力量来深入了解人类生物学

知识表示和推理(KR&R)已经成功地应用于许多领域，使计算机能够用人工智能方法解决复杂的问题。然而，它在生物医学上的应用一直滞后，部分原因是控制人类生理和病理的分子和细胞途径令人生畏的复杂性。在本文中，我们描述了可扩展精确医学知识引擎(SPOKE)的具体用途，SPOKE是一个开放的知识网络，将来自37个专业和人工管理数据库的管理信息连接到一个单一的属性图中，迄今为止有300万个节点和1500万条边。本文讨论的应用包括药物发现、COVID-19研究和慢性疾病诊断和管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ai Magazine 工程技术-计算机：人工智能

CiteScore

3.90

自引率

11.10%

发文量

审稿时长

>12 weeks

期刊介绍： AI Magazine publishes original articles that are reasonably self-contained and aimed at a broad spectrum of the AI community. Technical content should be kept to a minimum. In general, the magazine does not publish articles that have been published elsewhere in whole or in part. The magazine welcomes the contribution of articles on the theory and practice of AI as well as general survey articles, tutorial articles on timely topics, conference or symposia or workshop reports, and timely columns on topics of interest to AI scientists.