Prazosin Protects the Liver Against Renal Ischemia/Reperfusion Injury in Rats.

IF 1.7 Q3 PHARMACOLOGY & PHARMACY

Drug Research Pub Date : 2023-06-01 DOI:10.1055/a-2015-7976

Fatemeh Khajepour, Fariba Mahmoodpoor, Elmira Jafari, Farzad Kakaei, Farina Bahraminia, Shadi Aghajani, Sepideh Zununi Vahed, Yasin Bagheri

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Abstract

Acute kidney injury (AKI) is a common subsequent problem after many medical conditions. AKI is associated with distant organ dysfunction where systemic inflammation and oxidative stress play major roles. In this study, the effect of Prazosin, an α1-Adrenergic receptor antagonist, was investigated on the liver injury induced by kidney ischemia-reperfusion (I/R) in rats. Male adult Wistar rats (n=21) were divided into three groups: sham, kidney I/R, and kidney I/R pre-treated with Prazosin (1 mg/kg). Kidney I/R was induced by vascular clamping of the left kidney for 45 min to reduce the blood flow. Oxidative and antioxidant factors along with apoptotic (Bax, Bcl-2, caspase3), and inflammatory (NF-κβ, IL-1β, and IL-6) factors were measured in the liver at protein levels. Prazosin could reserve liver function (p<0.01) and increase glutathione level (p<0.05) after kidney I/R significantly. Malonil dialdehyde (MDA), a lipid peroxidation marker, was diminished more significantly in Prazosin-treated rats compared to the kidney I/R group (p<0.001). Inflammatory and apoptotic factors were diminished by Prazosin pre-treatment in the liver tissue (p<0.05). Pre-administration of Prazosin could preserve liver function and decrease its inflammatory and apoptotic factors under kidney I/R conditions.

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哌唑嗪对大鼠肝脏缺血再灌注损伤的保护作用。

急性肾损伤(AKI)是许多疾病后常见的后续问题。AKI与远端器官功能障碍有关，其中系统性炎症和氧化应激起主要作用。本实验研究α1-肾上腺素受体拮抗剂普拉唑嗪对大鼠肾缺血再灌注(I/R)肝损伤的影响。雄性成年Wistar大鼠21只，分为假手术组、肾I/R组和经吡唑嗪(1 mg/kg)预处理的肾I/R组。左肾血管夹持45min，减少血流量，诱导肾I/R。在蛋白水平上检测肝脏中氧化、抗氧化因子以及凋亡因子(Bax、Bcl-2、caspase3)和炎症因子(NF-κβ、IL-1β和IL-6)。哌唑嗪能保留肝功能(p

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来源期刊

Drug Research PHARMACOLOGY & PHARMACY-

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Drug Research (formerly Arzneimittelforschung) is an international peer-reviewed journal with expedited processing times presenting the very latest research results related to novel and established drug molecules and the evaluation of new drug development. A key focus of the publication is translational medicine and the application of biological discoveries in the development of drugs for use in the clinical environment. Articles and experimental data from across the field of drug research address not only the issue of drug discovery, but also the mathematical and statistical methods for evaluating results from industrial investigations and clinical trials. Publishing twelve times a year, Drug Research includes original research articles as well as reviews, commentaries and short communications in the following areas: analytics applied to clinical trials chemistry and biochemistry clinical and experimental pharmacology drug interactions efficacy testing pharmacodynamics pharmacokinetics teratology toxicology.