[Shigellosis attended in the emergency department of a regional hospital in southeastern Spain: from their presence to multiresistance].

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-01 DOI:10.37201/req/121.2022

E Rodríguez-Guerrero, S Herrera-León, E Gómez-Vicente, J M Navarro-Marí, J Gutiérrez-Fernández

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引用次数: 1

Abstract

Objective: In the bacterial etiology of severe acute infectious diarrhea, except that caused by Clostridioides difficile, most of them have an invasive character and antibiotic treatment will be necessary in specific situations. Shigella is a classic pathogen, in which it is crucial to know the sensitivity to different classic and alternative antimicrobials. The objective of this work was to analyze the presence of shigellosis and the rate of antibiotic resistance.

Methods: A descriptive-retrospective study of the reports of shigellosis of stool cultures issued between January 2016 and April 2022 was conducted.

Results: A total of 34 episodes (16 -47.1%- by Shigella sonnei) were observed, as of 2018. There were only 2 pediatric cases. The overall resistance rate to azithromycin, trimethoprim-sulfamethoxazole and ciprofloxacin was 52.9%, 64.7% and 44.1%, respectively. 26.5% were resistant to the 3 groups of antibiotics. There was a higher rate of resistance for S. sonnei. The emergence of resistance to cephalosporins in recent years stands out. Episodes of multidrug-resistant shigellosis were detected between 2020 (1 by S. flexneri) and 2022 (4 by S. sonnei).

Conclusions: The episodes of shigellosis are emerging in our environment with a higher rate of multi-resistance. In this context, current empirical treatments for acute enteroinvasive enteritis are at risk of failure, if necessary.

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[志贺氏菌病在西班牙东南部一家地区医院的急诊科就诊:从其存在到多重耐药性]。

目的:在严重急性感染性腹泻的细菌病因学中，除难辨梭状芽胞杆菌引起的腹泻外，其余均具有侵袭性，在特定情况下需要抗生素治疗。志贺氏菌是一种经典病原体，了解其对不同经典和替代抗菌素的敏感性至关重要。这项工作的目的是分析志贺氏菌病的存在和抗生素耐药率。方法:对2016年1月至2022年4月期间发布的粪便培养志贺氏菌病报告进行描述性回顾性研究。结果:截至2018年，共观察到34例(16例-47.1%)sonnei志贺氏菌。只有2例儿科病例。对阿奇霉素、甲氧苄啶-磺胺甲恶唑和环丙沙星的总耐药率分别为52.9%、64.7%和44.1%。26.5%的患者对3组抗生素耐药。sonnei的耐药率较高。近年来出现的对头孢菌素的耐药性尤为突出。在2020年(弗氏沙门氏菌1例)和2022年(索内沙门氏菌4例)之间发现了多重耐药志贺菌病。结论:志贺氏菌病在我国环境中不断出现，多重耐药率较高。在这种情况下，如果有必要，目前对急性肠侵入性肠炎的经验性治疗有失败的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.