Narrative Review: Peripheral Arterial Disease in Patients with Hyperuricemia and Gout.

IF 5.7 2区医学 Q1 RHEUMATOLOGY

Current Rheumatology Reports Pub Date : 2023-05-01 DOI:10.1007/s11926-023-01100-1

Nicole Leung, Charles Fang, Jay Pendse, Michael Toprover, Michael H Pillinger

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引用次数: 1

Abstract

Purpose of review: To discuss what is currently known about the association and potential mechanistic interactions of hyperuricemia and gout with peripheral arterial disease (PAD).

Recent findings: Gout patients are at increased risk for coronary artery disease, but less is known about their risk for PAD. Studies suggest that the presence of gout and hyperuricemia are associated with PAD independent of known established risk factors. Moreover, higher SU was found to be associated with greater odds of having PAD and was independently associated with decreased absolute claudication distance. Urate's role in free radical formation, platelet aggregation, vascular smooth muscle proliferation, and impaired endothelial vasodilation may promote atherosclerotic progression. Studies suggest that patients with hyperuricemia or gout are at higher risk for developing PAD. Evidence is stronger for the relationship between elevated SU and PAD than for gout and PAD, but more data is needed. Whether elevated SU serves as a marker or cause of PAD remains to be investigated.

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叙述性综述:高尿酸血症和痛风患者的外周动脉疾病。

综述的目的:讨论目前已知的高尿酸血症和痛风与外周动脉疾病(PAD)的关联和潜在的机制相互作用。最近的研究发现:痛风患者患冠状动脉疾病的风险增加，但对其患PAD的风险知之甚少。研究表明，痛风和高尿酸血症的存在与PAD相关，独立于已知的既定危险因素。此外，高SU被发现与患PAD的几率更高相关，并且与绝对跛行距离的减少独立相关。尿酸盐在自由基形成、血小板聚集、血管平滑肌增殖和内皮血管舒张受损中的作用可能促进动脉粥样硬化的进展。研究表明，患有高尿酸血症或痛风的患者患PAD的风险更高。与痛风和PAD相比，SU升高和PAD之间的关系的证据更强，但需要更多的数据。尿酸升高是否作为PAD的标志或原因仍有待研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Rheumatology Reports RHEUMATOLOGY-

CiteScore

11.20

自引率

0.00%

发文量

期刊介绍： This journal aims to review the most important, recently published research in the field of rheumatology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of rheumatologic conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as the many forms of arthritis, osteoporosis and metabolic bone disease, and systemic lupus erythematosus. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.