Efficacy and Safety of Glycyrrhizic Acid in Treatment of Autoimmune Hepatitis.

IF 4.8 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

American Journal of Chinese Medicine Pub Date : 2023-01-01 DOI:10.1142/S0192415X23500209

Xiaoyue Bi, Liu Yang, Yanjie Lin, Wen Deng, Tingting Jiang, Lu Zhang, Yao Lu, Wei Yi, Yao Xie, Minghui Li

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引用次数: 1

Abstract

To compare the long-term efficacy and safety of glycyrrhizic acid preparation and hormone treatment in patients with autoimmune hepatitis, we enrolled 377 patients in a study that lasted from January 2009 to January 2020. After performing propensity score matching, we included 58 patients in the hormone group and 58 in the glycyrrhizic acid preparation group in statistical analysis. We then compared the ratio of sustained biochemical responses at 48 weeks after treatment. Adverse events, including some incidence of decompensated liver cirrhosis and liver cancer, were evaluated. The results showed that a total of 61.8% of treated patients achieved complete biochemical remission. The cumulative biochemical remission rate in the hormone group and glycyrrhizic acid preparation group showed no significant difference (62.3% vs. 60.7%, [Formula: see text], [Formula: see text]). At the end of follow-up, the total bile acid in the hormone group was significantly higher than that in the glycyrrhizic acid preparation group (8.9[Formula: see text][Formula: see text]mol/L vs. 5.6[Formula: see text][Formula: see text]mol/L, [Formula: see text], [Formula: see text]). The incidence of adverse reactions in the hormone group was significantly higher than that in the glycyrrhizic acid preparation group (31.03% vs. 15.52%, [Formula: see text], [Formula: see text]). In conclusion, compared with the hormone treatment, glycyrrhizic acid preparation might be a safe and effective treatment for autoimmune hepatitis.

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甘草酸治疗自身免疫性肝炎的疗效和安全性。

为了比较甘草酸制剂和激素治疗对自身免疫性肝炎患者的长期疗效和安全性，我们在2009年1月至2020年1月期间招募了377名患者。经倾向评分匹配后，我们将58例患者分为激素组和58例甘草酸制剂组进行统计分析。然后我们比较了治疗后48周持续生化反应的比例。不良事件，包括一些失代偿性肝硬化和肝癌的发生率进行了评估。结果显示，61.8%的治疗患者达到完全生化缓解。激素组和甘草酸制剂组的累积生化缓解率差异无统计学意义(62.3% vs. 60.7%，[公式:见文]，[公式:见文])。随访结束时，激素组总胆汁酸显著高于甘草酸制剂组(8.9[公式:见文][公式:见文]mol/L vs. 5.6[公式:见文][公式:见文][公式:见文]，[公式:见文]，[公式:见文])。激素组不良反应发生率明显高于甘草酸制剂组(31.03% vs. 15.52%，[公式:见文]，[公式:见文])。综上所述，与激素治疗相比，甘草酸制剂可能是一种安全有效的自身免疫性肝炎治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Chinese Medicine 医学-全科医学与补充医学

CiteScore

9.90

自引率

8.80%

发文量

159

审稿时长

4.5 months

期刊介绍： The American Journal of Chinese Medicine, which is defined in its broadest sense possible, publishes original articles and essays relating to traditional or ethnomedicine of all cultures. Areas of particular interest include: Basic scientific and clinical research in indigenous medical techniques, therapeutic procedures, medicinal plants, and traditional medical theories and concepts; Multidisciplinary study of medical practice and health care, especially from historical, cultural, public health, and socioeconomic perspectives; International policy implications of comparative studies of medicine in all cultures, including such issues as health in developing countries, affordability and transferability of health-care techniques and concepts; Translating scholarly ancient texts or modern publications on ethnomedicine. The American Journal of Chinese Medicine will consider for publication a broad range of scholarly contributions, including original scientific research papers, review articles, editorial comments, social policy statements, brief news items, bibliographies, research guides, letters to the editors, book reviews, and selected reprints.