Inhibitory Deficits of Insomnia Disorder: A Meta-Analysis on Event Related Potentials in Auditory Oddball Task.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY

Behavioral Sleep Medicine Pub Date : 2024-01-02 Epub Date: 2023-03-29 DOI:10.1080/15402002.2023.2192499

Liyong Yu, Lu Yang, Hao Xu, Guangli Zhao, Zeyang Dou, Yucai Luo, Jie Yang, Qi Zhang, Siyi Yu

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引用次数: 0

Abstract

Background: Despite numerous studies on auditory event-related potentials (ERPs) in insomnia disorder (ID), the results are inconsistent across different ERP components (e.g. N1, P2, P3, and N350), types of auditory stimuli (e.g. standard and deviant), and stages of sleep (e.g. wakefulness, NREM sleep, and REM sleep). In light of this variability, we conducted a systematic meta-analysis of previous auditory ERP studies in ID to provide a quantitative review of the existing literature.

Methods: Relevant literatures were searched on the Embase, PubMed/MEDLINE, PsycINFO and Cochrane Library. A total of 12 studies comprising 497 participants were finally included in this meta-analysis. The study protocol was registered with PROSPERO under the registration number CRD42022308348.

Results: We found that patients with ID have significantly decreased N1 (Hedges' g = 0.34, 95%CI [0.04, 0.65]) and P3 (Hedges'g = -1.21, 95%CI [-2.37, -0.06]) amplitudes during wakefulness. In addition, decreases in P2 (Hedges'g = -0.57, 95%CI [-0.96, -0.17]) amplitude during wakefulness and N350 (Hedges' g = 0.73, 95%CI [0.36, 1.09]) amplitude during NREM.

Conclusions: This meta-analysis represents the first systematic investigation of ERP features across different stages of sleep in individuals with ID. Our results suggest that in patients with insomnia, the absence or deficiency of arousal inhibition during the nighttime sleep initiation or maintenance process may interfere with the normal process of sleep.

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失眠症的抑制缺陷：听觉怪球任务中事件相关电位的元分析

背景：尽管对失眠症（ID）的听觉事件相关电位（ERPs）进行了大量研究，但在不同的ERP成分（如N1、P2、P3和N350）、听觉刺激类型（如标准和偏差）和睡眠阶段（如清醒、NREM睡眠和REM睡眠）之间，研究结果并不一致。鉴于这种差异性，我们对以往的听觉ERP研究进行了系统的荟萃分析，对现有文献进行了定量回顾：方法：我们在 Embase、PubMed/MEDLINE、PsycINFO 和 Cochrane 图书馆中检索了相关文献。最终共有 12 项研究、497 名参与者被纳入此次荟萃分析。研究方案已在 PROSPERO 注册，注册号为 CRD42022308348：我们发现，ID 患者在清醒状态下的 N1（Hedges'g = 0.34，95%CI [0.04，0.65]）和 P3（Hedges'g =-1.21，95%CI [-2.37，-0.06]）振幅明显下降。此外，清醒时的 P2（Hedges'g = -0.57，95%CI [-0.96，-0.17]）振幅和 NREM 时的 N350（Hedges'g = 0.73，95%CI [0.36，1.09]）振幅也有所下降：这项荟萃分析首次对失眠症患者不同睡眠阶段的ERP特征进行了系统研究。我们的研究结果表明，失眠症患者在夜间睡眠启动或维持过程中缺乏或缺乏唤醒抑制，可能会干扰正常的睡眠过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioral Sleep Medicine CLINICAL NEUROLOGY-PSYCHIATRY

CiteScore

7.20

自引率

3.20%

发文量

审稿时长

>12 weeks

期刊介绍： Behavioral Sleep Medicine addresses behavioral dimensions of normal and abnormal sleep mechanisms and the prevention, assessment, and treatment of sleep disorders and associated behavioral and emotional problems. Standards for interventions acceptable to this journal are guided by established principles of behavior change. Intending to serve as the intellectual home for the application of behavioral/cognitive science to the study of normal and disordered sleep, the journal paints a broad stroke across the behavioral sleep medicine landscape. Its content includes scholarly investigation of such areas as normal sleep experience, insomnia, the relation of daytime functioning to sleep, parasomnias, circadian rhythm disorders, treatment adherence, pediatrics, and geriatrics. Multidisciplinary approaches are particularly welcome. The journal’ domain encompasses human basic, applied, and clinical outcome research. Behavioral Sleep Medicine also embraces methodological diversity, spanning innovative case studies, quasi-experimentation, randomized trials, epidemiology, and critical reviews.