Describing Engagement in the HIV Care Cascade: A Methodological Study.

IF 1.5 Q4 INFECTIOUS DISEASES
Diya Jhuti, Gohar Zakaryan, Hussein El-Kechen, Nadia Rehman, Mark Youssef, Cristian Garcia, Vaibhav Arora, Babalwa Zani, Alvin Leenus, Michael Wu, Oluwatoni Makanjuola, Lawrence Mbuagbaw
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Abstract

Introduction: Engagement in the HIV care cascade is required for people living with HIV (PLWH) to achieve an undetectable viral load. However, varying definitions of engagement exist, contributing to heterogeneity in research regarding how many individuals are actively participating and benefitting from care. A standardized definition is needed to enhance comparability and pooling of data from engagement studies.

Objectives: The objective of this paper was to describe the various definitions for engagement used in HIV clinical trials.

Methods: Articles were retrieved from CASCADE, a database of 298 clinical trials conducted to improve the HIV care cascade (https://hivcarecascade.com/), curated by income level, vulnerable population, who delivered the intervention, the setting in which it was delivered, the intervention type, and the level of pragmatism of the intervention. Studies with engagement listed as an outcome were selected from this database.

Results: 13 studies were eligible, of which five did not provide an explicit definition for engagement. The remaining studies used one or more of the following: appointment adherence (n=6), laboratory testing (n=2), adherence to antiretroviral therapy (n=2), time specification (n=5), intervention adherence (n=5), and quality of interaction (n=1).

Conclusion: This paper highlights the existing diversity in definitions for engagement in the HIV care cascade and categorize these definitions into appointment adherence, laboratory testing, adherence to antiretroviral therapy, time specification, intervention adherence, and quality of interaction. We recommend consensus on how to describe and measure engagement.

Abstract Image

Abstract Image

描述参与艾滋病毒护理级联:一项方法学研究。
导读:艾滋病毒感染者(PLWH)需要参与艾滋病毒护理级联,以实现无法检测到的病毒载量。然而,参与的不同定义存在,导致研究中关于有多少人积极参与并从护理中受益的异质性。需要一个标准化的定义来增强可比较性,并从敬业度研究中汇集数据。目的:本文的目的是描述在HIV临床试验中使用的参与的各种定义。方法:文章从CASCADE数据库中检索,该数据库包含298项临床试验,旨在改善HIV护理级联(https://hivcarecascade.com/),按收入水平、弱势人群、实施干预的人员、实施干预的环境、干预类型和干预的实用主义水平进行整理。从该数据库中选择将参与列为结果的研究。结果:13项研究符合条件,其中5项没有提供敬业度的明确定义。其余的研究使用了以下一项或多项:预约依从性(n=6)、实验室检测(n=2)、抗逆转录病毒治疗依从性(n=2)、时间规范(n=5)、干预依从性(n=5)和相互作用质量(n=1)。结论:本文强调了参与HIV护理级联的定义的多样性,并将这些定义分为预约依从性、实验室检测、抗逆转录病毒治疗依从性、时间规范、干预依从性和相互作用质量。我们建议就如何描述和衡量敬业度达成共识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.00
自引率
6.70%
发文量
61
审稿时长
16 weeks
期刊介绍: About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.
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