L-Tartaric Acid Exhibits Antihypertensive and Vasorelaxant Effects: The Possible Role of eNOS/NO/cGMP Pathways.

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2023-01-01 DOI:10.2174/1871525721666230111150501

Ayoub Amssayef, Ismail Bouadid, Mohamed Eddouks

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引用次数: 0

Abstract

Aims: The aim of the study was to investigate the antihypertensive effect of L-Tartaric acid.

Background: L-Tartaric acid (L-TA) is a well-known weak organic acid that naturally occurs in a wide range of fruits, most notably in grapes, tamarind, and citrus.

Objective: The present study aimed to assess the effect of acute and subchronic administration of L-TA on blood pressure parameters in normotensive and hypertensive rats as well as its vasorelaxant potency.

Methods: In the current study, the antihypertensive activity of L-TA was pharmacologically studied. L-NAME-induced hypertensive and normotensive rats received L-TA (80 and 240 mg/kg) orally over six hours for the acute experiment and seven days for the subchronic treatment. Thereafter, systolic, diastolic, mean, mid arterial blood pressure, and pulse pressure as well as heart rate were evaluated. In the in vitro experiment, the vasorelaxant ability of L-TA was performed in ratisolated thoracic aorta.

Results: An important drop in blood pressure was recorded in L-NAME-induced hypertensives treated with L-TA. This molecule also produced a dose-dependent relaxation of the aorta precontracted with norepinephrine (NEP) and KCl. The study demonstrated that the vasorelaxant capacity of L-TA seems to be exerted through the activation of eNOS/NO/cGMP pathways.

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l -酒石酸具有抗高血压和血管松弛作用:eNOS/NO/cGMP通路的可能作用

目的:探讨l -酒石酸的降压作用。背景:l-酒石酸(L-TA)是一种众所周知的弱有机酸，广泛存在于各种水果中，最明显的是葡萄、罗望子和柑橘。目的:观察左旋ta急性和亚慢性给药对正常和高血压大鼠血压参数的影响及其血管松弛作用。方法:对左旋ta的降压作用进行药理学研究。l - name诱导的高血压和正常高血压大鼠急性组给予L-TA(80和240 mg/kg)口服6小时，亚慢性组给予7天。然后，评估收缩压、舒张压、平均、中动脉压、脉压和心率。在体外实验中，对L-TA在解除胸主动脉上的血管松弛能力进行了研究。结果:L-TA治疗l - name诱导的高血压患者血压有明显下降。该分子还能产生剂量依赖性的去甲肾上腺素(NEP)和KCl预收缩的主动脉松弛。研究表明，L-TA的血管松弛能力似乎是通过激活eNOS/NO/cGMP途径发挥的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.