Advances in MDS/AML and inositide signalling

Q1 Biochemistry, Genetics and Molecular Biology

Advances in biological regulation Pub Date : 2023-01-01 DOI:10.1016/j.jbior.2023.100955

Alessia De Stefano , Maria Vittoria Marvi , Antonietta Fazio , James A. McCubrey , Pann-Ghill Suh , Stefano Ratti , Giulia Ramazzotti , Lucia Manzoli , Lucio Cocco , Matilde Y. Follo

引用次数: 1

Abstract

Aberrant signaling pathways regulating proliferation and differentiation of hematopoietic stem cells (HSCs) can contribute to disease pathogenesis and neoplastic growth. Phosphoinositides (PIs) are inositol phospholipids that are implicated in the regulation of critical signaling pathways: aberrant regulation of Phospholipase C (PLC) beta1, PLCgamma1 and the PI3K/Akt/mTOR pathway play essential roles in the pathogenesis of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML).

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MDS/AML和肌苷信号传导的研究进展

调节造血干细胞增殖和分化的异常信号通路可能有助于疾病的发病机制和肿瘤的生长。磷脂（PI）是一种与关键信号通路的调节有关的肌醇磷脂：磷脂酶C（PLC）β1、PLCγ1和PI3K/Akt/mTOR通路的异常调节在骨髓增生异常综合征（MDS）和急性髓细胞白血病（AML）的发病机制中起着重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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