Targeting Ferroptosis in Cancer by Natural Products: An Updated Review.

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2023-01-01 DOI:10.1142/S0192415X23500271

Zhengwang Guo, Shan Wang, Huifeng Hao, Xinxin Deng, Jialei Fu, Yang Guo, Yuan Yuan, Yanna Jiao, Shuyan Han

{"title":"Targeting Ferroptosis in Cancer by Natural Products: An Updated Review.","authors":"Zhengwang Guo, Shan Wang, Huifeng Hao, Xinxin Deng, Jialei Fu, Yang Guo, Yuan Yuan, Yanna Jiao, Shuyan Han","doi":"10.1142/S0192415X23500271","DOIUrl":null,"url":null,"abstract":"Ferroptosis is a new cell death process characterized by massive iron accumulation and lipid peroxidation. Emerging evidence demonstrates that ferroptosis plays a crucial role in the development and progression of tumorigenesis. Targeting it is a potentially effective cancer prevention and treatment strategy in the clinic. A comprehensive review of molecular mechanisms of targeting ferroptosis in cancer by natural products needs to be re-summarized and updated due to the advances in research. We searched and reviewed relevant literature through the database Web of Science, mainly focusing on the regulatory effects of natural products and their active compounds in treating or preventing cancer by regulating ferroptosis. A total of 62 kinds of natural products and their active compounds were reported to exert antitumor effects via causing ferroptosis of cancer cells by regulating the System Xc--GPX4 axis and lipid, mitochondrial, and iron metabolism. Natural products have advantages in improving chemotherapy's therapeutic effects by causing cancer cell ferroptosis through their polypharmacological actions. These molecular mechanisms of ferroptosis regulation by natural products will pave the way for developing natural antitumor drugs based on regulating ferroptosis.","PeriodicalId":4,"journal":{"name":"ACS Applied Energy Materials","volume":null,"pages":null},"PeriodicalIF":5.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Energy Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1142/S0192415X23500271","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

Ferroptosis is a new cell death process characterized by massive iron accumulation and lipid peroxidation. Emerging evidence demonstrates that ferroptosis plays a crucial role in the development and progression of tumorigenesis. Targeting it is a potentially effective cancer prevention and treatment strategy in the clinic. A comprehensive review of molecular mechanisms of targeting ferroptosis in cancer by natural products needs to be re-summarized and updated due to the advances in research. We searched and reviewed relevant literature through the database Web of Science, mainly focusing on the regulatory effects of natural products and their active compounds in treating or preventing cancer by regulating ferroptosis. A total of 62 kinds of natural products and their active compounds were reported to exert antitumor effects via causing ferroptosis of cancer cells by regulating the System Xc^--GPX4 axis and lipid, mitochondrial, and iron metabolism. Natural products have advantages in improving chemotherapy's therapeutic effects by causing cancer cell ferroptosis through their polypharmacological actions. These molecular mechanisms of ferroptosis regulation by natural products will pave the way for developing natural antitumor drugs based on regulating ferroptosis.

查看原文本刊更多论文

利用天然产物靶向癌症中的铁下垂:最新综述。

铁下垂是一种以大量铁积累和脂质过氧化为特征的新型细胞死亡过程。越来越多的证据表明，铁下垂在肿瘤发生的发展和进展中起着至关重要的作用。在临床上，靶向治疗是一种潜在有效的癌症防治策略。由于研究的进展，对天然产物靶向肿瘤铁下垂分子机制的全面综述需要重新总结和更新。我们通过Web of Science数据库检索并查阅相关文献，主要关注天然产物及其活性化合物通过调控铁凋亡治疗或预防癌症的调控作用。据报道，共有62种天然产物及其活性化合物通过调节系统Xc—GPX4轴以及脂质、线粒体和铁代谢而引起癌细胞铁凋亡，从而发挥抗肿瘤作用。天然产物通过其多药理作用引起癌细胞铁下垂，从而提高化疗的疗效。这些天然产物调控铁下垂的分子机制将为开发基于调控铁下垂的天然抗肿瘤药物铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.