Chunlong Yan, Dengfeng Tian, Chenhong Zhang, Qiang Zhang, Yanqiu Sun
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引用次数: 0
Abstract
Background: The purpose of this study was to explore the changes in blood cellular and biochemical parameters of rats in a natural environment of low pressure and low oxygen on the plateau.
Methods: Male Sprague-Dawley rats in two groups were raised in different environments from 4 weeks of age for a period of 24 weeks. They were raised to 28 weeks of age and then transported to the plateau medical laboratory of Qinghai University. Blood cellular and biochemical parameters were measured and the data of the two groups were statistically analyzed.
Results: 1. RBC in the HA group was higher than that in the Control group, but there was no significant difference between the two groups (p > 0.05), Compared with the Control group, HGB, MCV, MCH, MCHC and RDW in the HA group were significantly higher (p < 0.05). 2. Compared with the Control group, WBC, LYMP, EO, LYMP% and EO% in the HA group decreased significantly (p < 0.05), and ANC% increased significantly (p < 0.05). 3. In the platelet index, compared with the Control group, PLT in the HA group was significantly reduced (p < 0.05), PDW, MRV, P-LCR were significantly increased (p < 0.05). 4. In blood biochemical indicators, compared with the Control group, AST, TBIL, IBIL, LDH in the HA group decreased significantly (p < 0.05), CK in the HA group increased significantly (p < 0.05).
Conclusions: 1. The indexes related to red blood cells, white blood cells, platelets and some biochemical indexes in the blood of rats at high altitude have changed. 2. Under the high altitude environment, the oxygen carrying capacity of SD rats is improved, the resistance to disease may be reduced, the coagulation and hemostasis functions may be affected, and there is a risk of bleeding. The liver function, renal function, heart function and skeletal muscle energy metabolism may be affected. 3. This study can provide an experimental basis for the research on the pathogenesis of high-altitude diseases from the perspective of blood.KEY MESSAGESIn this study, red blood cells, white blood cells, platelets and blood biochemical indicators were included in the real plateau environment to comprehensively analyze the changes of blood cellular and biochemical parameters in rats under the chronic plateau hypobaric hypoxia environment.From the perspective of blood, this study can provide an experimental basis for research on the pathogenesis of high-altitude diseases.Explore the data support of oxygen-carrying capacity, disease resistance and energy metabolism of the body in the natural environment at high altitude.
背景：本研究旨在探讨高原低压低氧自然环境下大鼠血细胞和生化参数的变化。方法：雄性Sprague-Dawley大鼠分为两组，分别于4 周龄，24岁 周。他们被提高到28 周大，然后被送往青海大学高原医学实验室。测量两组患者的血细胞和生化参数，并对数据进行统计学分析。结果：1。HA组红细胞明显高于对照组，但两组间差异无统计学意义（p > HA组HGB、MCV、MCH、MCHC和RDW均明显高于对照组（p p p p p p p 结论：1。高原大鼠血液中红细胞、白细胞、血小板等相关指标及某些生化指标发生了变化。2.在高海拔环境下，SD大鼠的携氧能力提高，对疾病的抵抗力可能降低，凝血止血功能可能受到影响，有出血的风险。肝功能、肾功能、心功能和骨骼肌能量代谢可能受到影响。3.本研究可为从血液角度研究高原疾病的发病机制提供实验依据。关键信息在本研究中，将红细胞、白细胞、血小板和血液生化指标纳入真实的高原环境中，全面分析慢性高原低压缺氧环境下大鼠血细胞和生化参数的变化。从血液的角度，本研究可以为研究高原疾病的发病机制提供实验依据。探索高海拔自然环境下机体载氧能力、抗病能力和能量代谢的数据支撑。
期刊介绍：
Annals of Medicine is one of the world’s leading general medical review journals, boasting an impact factor of 5.435. It presents high-quality topical review articles, commissioned by the Editors and Editorial Committee, as well as original articles. The journal provides the current opinion on recent developments across the major medical specialties, with a particular focus on internal medicine. The peer-reviewed content of the journal keeps readers updated on the latest advances in the understanding of the pathogenesis of diseases, and in how molecular medicine and genetics can be applied in daily clinical practice.
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