Serum cystatin C and βeta-2 microglobulin as potential biomarkers in children with lupus nephritis.

IF 1.1 4区医学 Q4 Medicine

Archives of rheumatology Pub Date : 2023-03-01 DOI:10.46497/ArchRheumatol.2023.8520

Eman Baraka, Nashwa Hashaad, Walid Abdelhalim, Gehan Elolemy

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引用次数: 0

Abstract

Objectives: In this study, we aimed to assess serum levels of Cystatin C (Cys C) and beta-2 microglobulin (β2M) in juvenile systemic lupus erythematosus (JSLE) patients and to investigate their role as potential biomarkers of lupus nephritis (LN) and overall disease activity.

Patients and methods: Between December 2018 and November 2019, a total of 40 patients with JSLE (11 males, 29 females; mean age: 12.6±2.5 years; range, 7.5 to 16 years) and 40 age- and sex-matched controls (10 males, 30 females; mean age: 12.3±2.4 years; range, 7 to 16 years) were included in this study. Serum (s) Cys C and β2M levels were compared between the groups. The SLE Disease Activity Index (SLEDAI-2K), the renal SLEDAI (rSLEDAI), and the Renal Damage Index were used.

Results: JSLE patients had significantly elevated mean sCyc C and sβ2M levels (1.4±0.8 mg/mL and 2.8±0.9 mg/mL, respectively) compared to the controls (0.6±0.1 mg/mL and 2.0±0.2 mg/mL, respectively; p<0.00). The mean sCys C and sβ2M levels were significantly higher in the LN group, compared to non-LN patients (1.8±0.7 mg/mL and 3.1±1.0 mg/mL, respectively vs. 0.8±0.3 mg/mL and 2.4±0.6 mg/mL, respectively; p=0.002 and p=0.02, respectively). The sCys C levels had significant positive correlations with erythrocyte sedimentation rate (r=0.3, p=0.05), serum creatinine (r=0.41, p= 0.007), 24-h urinary protein (r=0.58, p<0.001), anti-double stranded deoxyribonucleic acid antibodies titers (r=0.55, p=0.002), extra-renal SLEDAI scores (r=0.36, p=0.04), rSLEDAI (r=0.46, p=0.002), and renal class (r=0.7, p=0.0001). Serum β2M levels were significantly negatively correlated with complement 4 levels (r=-0.31, p=0.04) and significantly positively correlated with extra-renal SLEDAI scores (r=0.3, p=0.05).

Conclusion: These findings confirm that sCys C and sβ2M levels are increased in JSLE patients in association with the overall active disease. However, sCys C level may act as a promising non-invasive biomarker for predicting kidney disease activity and biopsy classes in children with JSLE.

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血清胱抑素C和β β -2微球蛋白作为狼疮肾炎儿童的潜在生物标志物。

目的:在这项研究中，我们旨在评估青少年系统性红斑狼疮(JSLE)患者血清胱抑素C (Cys C)和β -2微球蛋白(β2M)水平，并探讨它们作为狼疮肾炎(LN)和整体疾病活动性的潜在生物标志物的作用。患者与方法:2018年12月至2019年11月，共40例JSLE患者(男11例，女29例;平均年龄:12.6±2.5岁;年龄范围:7.5岁至16岁)和40名年龄和性别匹配的对照组(10名男性，30名女性;平均年龄:12.3±2.4岁;范围，7至16岁)被纳入本研究。比较各组血清Cys C和β2M水平。采用SLE疾病活动性指数(SLEDAI- 2k)、肾脏SLEDAI (rSLEDAI)和肾脏损害指数。结果:与对照组(分别为0.6±0.1 mg/mL和2.0±0.2 mg/mL)相比，JSLE患者sCyc和s - β 2m平均水平显著升高(分别为1.4±0.8 mg/mL和2.8±0.9 mg/mL);结论:这些发现证实，sCys C和sβ2M水平在JSLE患者中升高与整体活动性疾病相关。然而，scysc水平可能作为一种有希望的非侵入性生物标志物，用于预测JSLE儿童肾脏疾病的活动性和活检类别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of rheumatology Medicine-Rheumatology

CiteScore

2.00

自引率

9.10%

发文量

期刊介绍： The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).