Association of pain and clinical factors on disability and quality of life in systemic sclerosis: A cross-sectional study from Turkish League Against Rheumatism Network.

IF 1.1 4区医学 Q4 Medicine

Archives of rheumatology Pub Date : 2022-11-11 eCollection Date: 2023-03-01 DOI:10.46497/ArchRheumatol.2023.9243

Remzi Çevik, Serda Em, Kemal Nas, Murat Toprak, Gizem Cengiz, Mustafa Çalış, İlhan Sezer, Ayşe Ünal Enginar, Pınar Bora Karslı, Sinem Sağ, Betül Sargın, Meltem Alkan Melikoğlu, Yıldıray Aydın, Mehmet Tuncay Duruöz, Halise Hande Gezer, Hilal Ecesoy

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引用次数: 0

Abstract

Objectives: In this study, we aimed to evaluate the factors associated with disability and quality of life (QoL) in Turkish patients with systemic sclerosis (SSc).

Patients and methods: Between January 2018 and January 2019, a total of 256 SSc patients (20 males, 236 females; mean age: 50.9±12.4 years; range, 19 to 87 years) who were diagnosed with SSc were included in the study. Disability and health-related QoL (HRQoL) were evaluated by the Health Assessment Questionnaire (HAQ), scleroderma HAQ (SHAQ), Duruöz Hand Index (DHI), and Short Form-36 (SF-36). Linear regression analysis methods were used to describe factors associated with disability and QoL of the patients.

Results: All disability scores were higher and HRQoL scores were lower in diffuse cutaneous SSc patients compared limited cutaneous SSc, and differentiations were significant (p=0.001 and p=0.007). In multiple regression, pain (VAS) was the strongest predictor for high disability and low QoL scores (p<0.001) as HAQ (β=0.397, 0.386, 0.452), SHAQ (β=0.397, 0.448, 0.372), DHI (β=0.446, 0.536, 0.389), PCS (β=-0.417,-0.499, -0.408) and MCS (β=-0.478, -0.441, -0.370) in combined, lcSSc and dcSSc patients respectively. The factors associated with high disability and low QoL scores were forced vital capacity for HAQ (β=-0.172, p=0.002) and SF-36 PCS (β=0.187, p=0.001); disease duration for HAQ (β=0.208, p<0.001), DHI (β=0.147, p=0.006), and SF-36 PCS (β=-0.134, p=0.014); 6-minute walk test for HAQ (β=-0.161, p=0.005) and SF-36 PCS (β=0.153, p=0.009); and modified Rodnan skin score for SHAQ (β=0.250, p<0.001) and DHI (β=0.233, p<0.001) in SSc patients. Diffusing capacity of the lungs for carbon monoxide for HAQ (β=-0.189, p=0.010) and SHAQ (β=-0.247, p=0.002); erythrocyte sedimentation rate for DHI (β=0.322, p<0.001); age for SF-36 PCS (β=-0.221, p=0.003) and body mass index for SF-36 PCS (β=-0.200, p=0.008) and MCS (β=-0.175, p=0.034) were the other variables associated with high disability or low QoL scores in SSc subsets.

Conclusion: Clinicians should consider the management of the pain and its sources as a key to improve better functional state and quality of daily life in SSc.

查看原文本刊更多论文

系统性硬化症患者的疼痛和临床因素对残疾和生活质量的影响：来自土耳其抗风湿联盟网络的横断面研究。

研究目的本研究旨在评估土耳其系统性硬化症（SSc）患者残疾和生活质量（QoL）的相关因素：在 2018 年 1 月至 2019 年 1 月期间，共有 256 名确诊为 SSc 的患者（男性 20 人，女性 236 人；平均年龄：50.9±12.4 岁；范围：19 至 87 岁）被纳入研究。通过健康评估问卷（HAQ）、硬皮病HAQ（SHAQ）、Duruöz手指数（DHI）和短表格-36（SF-36）对残疾和健康相关生活质量（HRQoL）进行评估。采用线性回归分析方法描述了与患者残疾和 QoL 相关的因素：结果：与局限性皮肤型 SSc 相比，弥漫性皮肤型 SSc 患者的所有残疾评分均较高，HRQoL 评分较低，且差异显著（P=0.001 和 P=0.007）。在多元回归中，疼痛（VAS）是预测高残疾和低 QoL 评分的最有力因素（p 结论：临床医生应考虑对弥漫性皮肤型 SSc 患者进行治疗：临床医生应将疼痛及其来源的管理视为改善 SSc 患者功能状态和日常生活质量的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of rheumatology Medicine-Rheumatology

CiteScore

2.00

自引率

9.10%

发文量

期刊介绍： The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).