Salivary anti-cyclic citrullinated peptide as a screening tool for rheumatoid arthritis.

IF 1.1 4区医学 Q4 Medicine

Archives of rheumatology Pub Date : 2023-03-01 DOI:10.46497/ArchRheumatol.2023.9032

Nazanin Mortazavi, Nafiseh Abdolahi, Mohsen Saeidi, Mohammad Ali Vakili, Pouria Mohebrad

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Abstract

Objectives: This study aims to evaluate the sensitivity and specificity of salivary anti-cyclic citrullinated peptide 3 (anti-CCP3) for the early diagnosis of rheumatoid arthritis.

Patients and methods: Between June 2017 and April 2019, a total of 63 patients with rheumatoid arthritis (10 males, 53 females; mean age: 50.4±9.5 years; range, 27 to 74 years) and 49 healthy controls (8 males, 41 females; mean age: 49.3±9.3 years; range 27 to 67 years) were included. Salivary samples were collected by passive drooling. Anti-cyclic citrullinated peptide analyses of salivary and serum samples were performed.

Results: The mean polyclonal immunoglobulin (Ig)G-IgA anti-CCP3 salivary levels were significantly different in patients (149.2±134.2) compared to healthy controls (28.5±23.9). The mean polyclonal IgG-IgA anti-CCP3 serum levels were measured as 254.0±169.5 in patients and 3.8±3.6 in healthy individuals. The diagnostic accuracy analysis of salivary IgG-IgA anti-CCP3 results in an area under the curve (AUC) of 0.818, as well as 91.84% specificity and 61.90% sensitivity.

Conclusion: Salivary anti-CCP3 may be considered as an additional screening test for rheumatoid arthritis.

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唾液抗环瓜氨酸肽作为类风湿关节炎的筛查工具。

目的:本研究旨在评价唾液抗环瓜氨酸肽3 (anti-CCP3)在类风湿关节炎早期诊断中的敏感性和特异性。患者和方法:2017年6月至2019年4月，共63例类风湿性关节炎患者(男性10例，女性53例;平均年龄:50.4±9.5岁;年龄在27岁至74岁之间)和49名健康对照者(8名男性，41名女性;平均年龄49.3±9.3岁;年龄范围为27至67岁)。采用被动流涎法采集唾液样本。唾液和血清样品进行抗环瓜氨酸肽分析。结果:患者唾液多克隆免疫球蛋白(Ig)G-IgA抗ccp3水平(149.2±134.2)显著高于健康对照组(28.5±23.9)。患者血清IgG-IgA抗ccp3平均水平为254.0±169.5，健康人平均水平为3.8±3.6。唾液IgG-IgA抗ccp3的诊断准确率分析为曲线下面积(AUC)为0.818，特异性为91.84%，敏感性为61.90%。结论:唾液抗ccp3可作为类风湿关节炎的附加筛查试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of rheumatology Medicine-Rheumatology

CiteScore

2.00

自引率

9.10%

发文量

期刊介绍： The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).