A biological and a mathematical model of SLE treated by mesenchymal stem cells covering all the stages of the disease.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-01 DOI:10.1007/s12064-023-00390-4

Ali Yazdani, Fariba Bahrami, Arash Pourgholaminejad, Reza Moghadasali

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Abstract

In this study, we proposed a biological model explaining the progress of autoimmune activation along different stages of systemic lupus erythematosus (SLE). For any upcoming stage of SLE, any new component is introduced, when it is added to the model. Particularly, the interaction of mesenchymal stem cells, with the components of the model, is specified in a way that both the inflammatory and anti-inflammatory functions of these cells would be covered. The biological model is then recapitulated to a model with less complexity that explains the main features of the problem. Later, a 7th-order mathematical model for SLE is proposed, based on this simplified model. Finally, the range of validity of the proposed mathematical model was assessed. For this purpose, we simulated the model and analyzed the simulation results in case of some known behaviors of the disease, such as tolerance breach, the appearance of systemic inflammation, development of clinical signs, and occurrence of flares and improvements. The model was able to reproduce these events, qualitatively.

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间充质干细胞治疗SLE的生物学和数学模型，涵盖疾病的所有阶段。

在这项研究中，我们提出了一个生物学模型来解释自身免疫激活在系统性红斑狼疮(SLE)不同阶段的进展。对于SLE的任何即将到来的阶段，当它被添加到模型中时，将引入任何新组件。特别是，间充质干细胞的相互作用，与模型的组成部分，被指定的方式，这些细胞的炎症和抗炎功能将被覆盖。然后将生物学模型概括为一个不那么复杂的模型，该模型可以解释问题的主要特征。在此基础上，提出了系统性红斑狼疮的七阶数学模型。最后，对所提数学模型的有效性范围进行了评估。为此，我们对该模型进行了模拟，并分析了该疾病的一些已知行为，如耐受性破坏、全身性炎症的出现、临床体征的发展、发作和改善的发生等情况下的模拟结果。该模型能够定性地再现这些事件。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.