Relationship between the prognostic nutritional index and resistant hypertension in patients with essential hypertension.

IF 1.5 4区医学 Q3 PERIPHERAL VASCULAR DISEASE

Clinical and Experimental Hypertension Pub Date : 2022-05-19 DOI:10.1080/10641963.2022.2036995

Fatih Yılmaz, Meryem Keleş, Feyza Bora

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引用次数: 2

Abstract

Objectives: Immune system activation plays a role in resistant hypertension (RHTN) pathogenesis. The clinical effect of the prognostic nutritional index (PNI) on patients with RHTN remains unclear. The aim of this study investigated the possible correlation between PNI and RHTN.

Methods: In this cross-sectional study, we enrolled 180 adult subjects. In patients were classified into three groups according to their office and ambulatory blood pressure measurements (ABPM): RHTN (n = 60), controlled hypertension (CHTN, n = 60), and normotension-control (NT-C, n = 60). RHTN was defined as BP ≥140/90 mm Hg while taking ≥3 antihypertensive medications or BP <140/90 mm Hg while taking ≥4 medications. The PNI was calculated from the 10 x serum albumin (g/dL) + 0.005 x total lymphocyte count (/μL) formula.

Results: Office and ABPM were significantly higher in patients with RHTN. Patients in the RHTN (46.1 ± 5.3) had significantly lower PNI than that in the CHTN (54.9 ± 6.7) (P = .032), and PNIs of both hypertensive groups were significantly lower than the NT-C group (P = .019, for both). The ROC curve analysis performed to assess the predictive value of PNI for RHTN and using 50.9 optimal cutoff value of PNI for RHTN gave a sensitivity of 77% and a specificity of 68.5% (AUC = 0.73, 95% CI 0.69-0.96).Multivariate analysis indicated diabetes, 24-h ABPM SBP, CRP, pill burden, and PNI (<51.6) as independent predictors of RHTN.

Conclusion: This study showed that the level of PNI was significantly lower in patients with RHTN compared to patients with CHTN. PNI is independently related to RHTN.

查看原文本刊更多论文

原发性高血压患者预后营养指数与顽固性高血压的关系。

目的:免疫系统激活在顽固性高血压(RHTN)发病机制中起重要作用。预后营养指数(PNI)对RHTN患者的临床影响尚不清楚。本研究的目的是探讨PNI与RHTN之间可能的相关性。方法:在横断面研究中，我们招募了180名成人受试者。根据患者的办公室和动态血压测量(ABPM)将患者分为三组:RHTN (n = 60)，控制高血压(CHTN, n = 60)和正常血压控制(NT-C, n = 60)。RHTN定义为在服用≥3种抗高血压药物或血压时血压≥140/90 mm Hg。结果:RHTN患者的Office和ABPM显著升高。RHTN组患者PNI(46.1±5.3)显著低于CHTN组(54.9±6.7)(P = 0.032)，两组高血压患者PNI均显著低于NT-C组(P = 0.019)。ROC曲线分析评估PNI对RHTN的预测价值，采用50.9的最佳PNI截断值对RHTN的敏感性为77%，特异性为68.5% (AUC = 0.73, 95% CI 0.69-0.96)。多因素分析提示糖尿病、24小时ABPM SBP、CRP、药物负担和PNI(结论:本研究显示RHTN患者的PNI水平明显低于CHTN患者。PNI与RHTN独立相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Experimental Hypertension 医学-外周血管病

CiteScore

3.90

自引率

0.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical and Experimental Hypertension is a reputable journal that has converted to a full Open Access format starting from Volume 45 in 2023. While previous volumes are still accessible through a Pay to Read model, the journal now provides free and open access to its content. It serves as an international platform for the exchange of up-to-date scientific and clinical information concerning both human and animal hypertension. The journal publishes a wide range of articles, including full research papers, solicited and unsolicited reviews, and commentaries. Through these publications, the journal aims to enhance current understanding and support the timely detection, management, control, and prevention of hypertension-related conditions. One notable aspect of Clinical and Experimental Hypertension is its coverage of special issues that focus on the proceedings of symposia dedicated to hypertension research. This feature allows researchers and clinicians to delve deeper into the latest advancements in this field. The journal is abstracted and indexed in several renowned databases, including Pharmacoeconomics and Outcomes News (Online), Reactions Weekly (Online), CABI, EBSCOhost, Elsevier BV, International Atomic Energy Agency, and the National Library of Medicine, among others. These affiliations ensure that the journal's content receives broad visibility and facilitates its discoverability by professionals and researchers in related disciplines.