Greater Number of Plasma Exchanges Does Not Improve Outcome in Myasthenic Crisis.

Q3 Medicine

Journal of Clinical Neuromuscular Disease Pub Date : 2023-06-01 DOI:10.1097/CND.0000000000000421

Michael Hansen, Lee Neilson, Melanie Parikh, Bashar Katirji

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引用次数: 0

Abstract

Objectives: To determine the relationship between the number of plasma exchanges and clinical outcome in patients experiencing myasthenic crisis.

Methods: We retrospectively reviewed all episodes of myasthenia gravis exacerbation/crisis who received plasmapheresis in patients admitted to a single-center tertiary care referral center from July 2008 to July 2017. We performed statistical analyses to determine whether the increased number of plasma exchanges improves the primary outcome (hospital length of stay) and the secondary outcome (disposition to home, skilled nursing facility, long-term acute care hospital, or death).

Results: There is neither clinically observable nor statistically significant improvement in length of stay or disposition on discharge in patients who received 6 or greater sessions of plasmapheresis.

Conclusions: This study provides class IV evidence that extending the number of plasma exchanges beyond 5 does not correlate with decreased hospital length of stay or improved discharge disposition in patients experiencing myasthenic crisis.

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大量的血浆交换并不能改善肌无力危象的预后。

目的：确定经历肌无力危象的患者血浆交换次数与临床结果之间的关系。方法：我们回顾性回顾了2008年7月至2017年7月入住单中心三级护理转诊中心接受血浆置换的重症肌无力恶化/危象的所有发作。我们进行了统计分析，以确定血浆交换次数的增加是否改善了主要结果（住院时间）和次要结果（居家、熟练护理机构、长期急性护理医院或死亡）接受6次或6次以上血浆置换的患者出院。结论：这项研究提供了IV级证据，证明在经历肌无力危象的患者中，将血浆交换次数延长到5次以上与住院时间缩短或出院倾向改善无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neuromuscular Disease Medicine-Medicine (all)

CiteScore

1.60

自引率

0.00%

发文量

期刊介绍： Journal of Clinical Neuromuscular Disease provides original articles of interest to physicians who treat patients with neuromuscular diseases, including disorders of the motor neuron, peripheral nerves, neuromuscular junction, muscle, and autonomic nervous system. Each issue highlights the most advanced and successful approaches to diagnosis, functional assessment, surgical intervention, pharmacologic treatment, rehabilitation, and more.