Recent progress in the biology and physiology of BMP-8a.

IF 2.8 4区医学 Q3 CELL BIOLOGY

Connective Tissue Research Pub Date : 2023-05-01 DOI:10.1080/03008207.2022.2160326

Jiawei Tang, Miao Tan, Siqi Liao, Mengwei Pang, Jie Li

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引用次数: 0

Abstract

Purpose: BMP-8a is a member of bone morphogenetic proteins (BMPs) and plays a regulatory role in human growth and development as a transcription regulator. This review aims to summarize the current research on the impact and mechanism of BMP-8a in female and male reproduction, formation and eruption of teeth, bone and cartilage development, tissue differentiation, disease occurrence, progression and prognosis.

Methods: The phrases "BMP-8a," "BMPs," "regulator," "mechanism," "osteoblast," "cartilage," "cancer," "disease," and "inflammation" were searched in the PubMed database. The abstracts were evaluated, and a series of original publications and reviews were examined.

Results: According to the search, BMP-8a affects the development of the uterus by inhibiting luteinization and plays an important role in late spermatogenesis. It is highly expressed in osteogenesis and differentially expressed in chondrogenesis. Furthermore, BMP-8a has a significant impact on the occurrence, development and prognosis of various diseases.

Conclusions: BMP-8a regulates important factors and pathways, such as SMAD2/3 and SMAD1/5/8, to promote or inhibit the developmental processes of human reproductive organs. BMP-8a is also a member of the BMP family of proteins that regulates chondrogenesis and osteogenesis. In addition to its osteoinductive capabilities, BMP-8a is involved in the progression of diverse cancers.

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BMP-8a生物学和生理学研究进展。

目的:BMP-8a是骨形态发生蛋白(bone morphogenetic proteins, BMPs)的一员，作为转录调控因子在人类生长发育中发挥调控作用。本文就BMP-8a在男女生殖、牙齿形成与出牙、骨软骨发育、组织分化、疾病发生、进展及预后等方面的影响及机制进行综述。方法:在PubMed数据库中检索“BMP-8a”、“bmp”、“调节器”、“机制”、“成骨细胞”、“软骨”、“癌症”、“疾病”和“炎症”等短语。对摘要进行了评估，并对一系列原始出版物和评论进行了审查。结果:经检索，BMP-8a通过抑制黄体生成影响子宫发育，在后期精子发生中发挥重要作用。它在成骨过程中高表达，在软骨形成过程中差异表达。此外，BMP-8a对多种疾病的发生、发展和预后均有显著影响。结论:BMP-8a调节SMAD2/3、SMAD1/5/8等重要因子和通路，促进或抑制人类生殖器官的发育过程。BMP-8a也是BMP家族蛋白的一员，该家族蛋白调节软骨形成和成骨。除了其骨诱导能力外，BMP-8a还参与多种癌症的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Connective Tissue Research 生物-细胞生物学

CiteScore

6.60

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology. The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented. The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including Biochemistry Cell and Molecular Biology Immunology Structural Biology Biophysics Biomechanics Regenerative Medicine The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.