Differences in Clinical and Lab Characteristics of Sepsis between Opium User Patients and Patients with No Illicit Drug Addiction.

Q2 Medicine

Cardiovascular and Hematological Agents in Medicinal Chemistry Pub Date : 2024-01-01 DOI:10.2174/1871525721666230518101627

Omid Mehrpour, Effat Alemzadeh, Saeedeh Ghasemi, Tahereh Farkhondeh, Masood Ziaee

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引用次数: 0

Abstract

Background: Sepsis is a significant cause of mortality worldwide. This study aimed to compare clinical and laboratory characteristics of sepsis in patients addicted to illicit drugs versus patients with no illicit drug addiction.

Methods: In this cross-sectional study, all patients hospitalized with sepsis diagnosis were recruited within six months from September to March 2019. Sixty patients for each group (illicit drugaddicted and non-addicted individuals) were selected. The data relating to illicit drug consumption, serum indices, the current focus of infection, duration of hospitalization, and disease outcomes were collected. Patients who had an illicit drug addiction were compared with non-addicted patients in terms of clinical and laboratory parameters. The data collected were analyzed using SPSS software (version 19).

Results: The bacterial load in the urine culture was statistically significant in both groups and higher in the non-addicted group. The frequency distributions of focus of infection, duration of hospitalization, and outcome were not significantly different between the two groups. The serum sodium and total neutrophils were significantly higher in the addicted group. However, the MCHC level was significantly lower (p < 0.05).

Conclusion: Opium may have stimulated the immune system and reduced bacterial infection in septic patient users.

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鸦片吸食者和无非法药物成瘾者败血症临床和实验室特征的差异。

背景：败血症是全球死亡的重要原因。本研究旨在比较非法药物成瘾患者与无非法药物成瘾患者败血症的临床和实验室特征：在这项横断面研究中，从 2019 年 9 月至 3 月的 6 个月内，招募了所有被诊断为败血症的住院患者。每组（非法药物成瘾者和非成瘾者）各选取 60 名患者。收集了与非法药物消费、血清指数、当前感染病灶、住院时间和疾病结果相关的数据。在临床和实验室参数方面，对非法药物成瘾患者与非成瘾患者进行了比较。收集的数据使用 SPSS 软件（19 版）进行分析：结果：两组尿液培养的细菌量均有统计学意义，非吸毒成瘾组的细菌量更高。两组患者的感染病灶、住院时间和治疗结果的频率分布无明显差异。成瘾组的血清钠和中性粒细胞总数明显高于非成瘾组。结论：结论：鸦片可能刺激了脓毒症患者的免疫系统，减少了细菌感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular and Hematological Agents in Medicinal Chemistry Medicine-Cardiology and Cardiovascular Medicine

CiteScore

2.70

自引率

0.00%

发文量

期刊介绍： Cardiovascular & Hematological Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new Cardiovascular & Hematological Agents. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in Cardiovascular & Hematological medicinal chemistry. Cardiovascular & Hematological Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cardiovascular & hematological drug discovery.