Establishment of reference intervals for complete blood count in times of COVID-19 and vaccination.

IF 3.8 3区医学 Q1 MEDICAL LABORATORY TECHNOLOGY

Biochemia Medica Pub Date : 2023-06-15 DOI:10.11613/BM.2023.020701

Claudia Mendieta-Gutiérrez, Selene Chávez-González, Brenda Ivonne Rodríguez-Romero, Jazmín Anahí Sánchez-Garrido, Arturo Figueroa-Gómez, Jesús Bernabé Licona-Vela, Arturo Cuauhtémoc Juárez-Pérez, Alejandro Cabello-López, Guadalupe Aguilar-Madrid, Carmina Jiménez-Ramírez

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Abstract

Introduction: COVID-19 and vaccination may affect some parameters of the complete blood count (CBC). The aim of this study was to determine reference intervals (RI) of CBC in healthy population with different COVID-19 and vaccination backgrounds and compare them with those established previously.

Materials and methods: A cross-sectional study was conducted in donors who attended the Traumatology Hospital "Dr. Victorio de la Fuente Narváez" (HTVFN) from June to September 2021. Reference intervals were established using the non-parametric method on Sysmex XN-1000. For differences between groups with different COVID-19 and vaccination backgrounds, non-parametric tests were used.

Results: The RI were established in 156 men and 128 women. Haemoglobin (Hb), haematocrit (Hct), red blood cells (RBC), platelets (Plt), mean platelets volume (MPV), monocytes and relative neutrophils were higher in men than women (P < 0.001). The percentiles of Hb, Hct, RBC, MPV and relative monocytes showed higher values; Plt, white blood cells (WBC), lymphocytes, monocytes, neutrophils, eosinophils and absolute basophils, the 2.5th was higher and the 97.5th was lower; for lymphocytes and relative neutrophils, both percentiles had a trend toward lower values, compared to previous RI. Differences between groups with different COVID-19 and vaccination backgrounds, in lymphocytes (P = 0.038), neutrophils (P = 0.017) and eosinophils (P = 0.018) in men; Hct (P = 0.014), RDW (P = 0.023) in women and MPV (P = 0.001) in both, were not considered pathological.

Conclusions: The RI for the CBC were established in a Mestizo-Mexican population with different COVID-19 and vaccination backgrounds, so should be updated and validated in different hospitals close to the HTVFN that use the same analyser.

查看原文本刊更多论文

建立COVID-19和疫苗接种期间全血细胞计数参考区间。

导语:COVID-19和疫苗接种可能影响全血细胞计数(CBC)的某些参数。本研究的目的是确定不同COVID-19和疫苗接种背景的健康人群CBC的参考区间(RI)，并将其与先前建立的参考区间进行比较。材料和方法:对2021年6月至9月在创伤医院“Dr. Victorio de la Fuente Narváez”(HTVFN)就诊的供体进行了横断面研究。采用非参数法在Sysmex XN-1000上建立参考区间。对于不同COVID-19和疫苗接种背景的组间差异，采用非参数检验。结果:在156名男性和128名女性中建立了RI。血红蛋白(Hb)、红细胞压积(Hct)、红细胞(RBC)、血小板(Plt)、平均血小板体积(MPV)、单核细胞和相对中性粒细胞男性高于女性(P < 0.001)。Hb、Hct、RBC、MPV和相对单核细胞的百分位数较高;白细胞(WBC)、淋巴细胞、单核细胞、中性粒细胞、嗜酸性粒细胞和绝对嗜碱性粒细胞，2.5较高，97.5较低;对于淋巴细胞和相对中性粒细胞，与先前的RI相比，这两个百分位数都有降低的趋势。不同COVID-19和疫苗接种背景组男性淋巴细胞(P = 0.038)、中性粒细胞(P = 0.017)和嗜酸性粒细胞(P = 0.018)的差异;女性的Hct (P = 0.014)、RDW (P = 0.023)和MPV (P = 0.001)不被认为是病理。结论:CBC的RI是在具有不同COVID-19和疫苗接种背景的墨西哥混血人群中建立的，因此应在靠近HTVFN的不同医院使用相同的分析仪进行更新和验证。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemia Medica 医学-医学实验技术

CiteScore

5.50

自引率

3.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Journal provides a wide coverage of research in all aspects of clinical chemistry and laboratory medicine. Following categories fit into the scope of the Journal: general clinical chemistry, haematology and haemostasis, molecular diagnostics and endocrinology. Development, validation and verification of analytical techniques and methods applicable to clinical chemistry and laboratory medicine are welcome as well as studies dealing with laboratory organization, automation and quality control. Journal publishes on a regular basis educative preanalytical case reports (Preanalytical mysteries), articles dealing with applied biostatistics (Lessons in biostatistics) and research integrity (Research integrity corner).

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