Mapping the human sperm proteome - novel insights into reproductive research.

IF 3.8 3区生物学 Q1 BIOCHEMICAL RESEARCH METHODS

Expert Review of Proteomics Pub Date : 2023-01-01 DOI:10.1080/14789450.2023.2210764

Mika Alexia Miyazaki, Raquel Lozano Guilharducci, Paula Intasqui, Ricardo Pimenta Bertolla

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引用次数: 1

Abstract

Introduction: Spermatozoa are highly specialized cells with unique morphology. In addition, spermatozoa lose a considerable amount of cytoplasm during spermiogenesis, when they also compact their DNA, resulting in a transcriptionally quiescent cell. Throughout the male reproductive tract, sperm will acquire proteins that enable them to interact with the female reproductive tract. After ejaculation, proteins undergo post-translational modifications for sperm to capacitate, hyperactivate, and fertilize the oocyte. Many proteins have been identified as predictors of male infertility and also investigated in diseases that compromise reproductive potential.

Areas covered: In this review, we proposed to summarize the recent findings about the sperm proteome and how they affect sperm structure, function, and fertility. A literature search was performed using PubMed and Google Scholar databases within the past 5 years until August 2022.

Expert opinion: Sperm function depends on protein abundance, conformation, and PTMs; understanding the sperm proteome may help to identify pathways essential to fertility, even making it possible to unravel the mechanisms involved in idiopathic infertility. In addition, proteomics evaluation offers knowledge regarding alterations that compromise the male reproductive potential.

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绘制人类精子蛋白质组图——生殖研究的新见解。

精子是高度特化的细胞，具有独特的形态。此外，在精子发生过程中，精子失去了相当数量的细胞质，同时它们也压缩了它们的DNA，导致转录静止细胞。在整个男性生殖道中，精子会获得蛋白质，使它们能够与女性生殖道相互作用。射精后，蛋白质经过翻译后的修饰，使精子能化、超激活并使卵母细胞受精。许多蛋白质已被确定为男性不育的预测因子，并在损害生殖潜力的疾病中进行了研究。涉及领域:本文就精子蛋白质组及其对精子结构、功能和生育能力的影响等方面的研究进展进行综述。使用PubMed和Google Scholar数据库进行文献检索，检索时间为过去5年至2022年8月。专家意见:精子功能取决于蛋白质丰度、构象和PTMs;了解精子蛋白质组可能有助于确定对生育至关重要的途径，甚至使揭示特发性不孕症的机制成为可能。此外，蛋白质组学评估提供了有关损害男性生殖潜力的改变的知识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Proteomics 生物-生化研究方法

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Expert Review of Proteomics (ISSN 1478-9450) seeks to collect together technologies, methods and discoveries from the field of proteomics to advance scientific understanding of the many varied roles protein expression plays in human health and disease. The journal coverage includes, but is not limited to, overviews of specific technological advances in the development of protein arrays, interaction maps, data archives and biological assays, performance of new technologies and prospects for future drug discovery. The journal adopts the unique Expert Review article format, offering a complete overview of current thinking in a key technology area, research or clinical practice, augmented by the following sections: Expert Opinion - a personal view on the most effective or promising strategies and a clear perspective of future prospects within a realistic timescale Article highlights - an executive summary cutting to the author''s most critical points.