Peptide from NSP7 is able to form amyloid-like fibrils: Artifact or challenge to drug design?

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2023-02-01 DOI:10.1016/j.bbapap.2022.140884

Yuri Garmay , Aleksandr Rubel , Vladimir Egorov

引用次数: 1

Abstract

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We found potential amyloidogenic fragment in NSP7 SARS-CoV2 protein in silico
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NSP7 (52–62) fragment is able to form amyloid-like fibrils
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The possibility of using such a peptide as the basis for an antiviral drug is discussed

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来自NSP7的肽能够形成淀粉样蛋白样原纤维:人工产物还是对药物设计的挑战?

•我们在NSP7 SARS-CoV2蛋白中发现了潜在的淀粉样蛋白片段•NSP7(52-62)片段能够形成淀粉样原纤维•讨论了使用这种肽作为抗病毒药物基础的可能性

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464