Effect of Fennel-Valerian Extract on Hot Flashes and Sleep Disorders in Postmenopausal Women: A Randomized Trial.

Journal of Menopausal Medicine Pub Date : 2023-04-01 DOI:10.6118/jmm.22026

Ensiyeh Jenabi, Salman Khazaei, Soodabeh Aghababaei, Shirin Moradkhani

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Abstract

Objectives: This study aims to evaluate the effect of a mixture of fennel and valerian extracts on hot flashes and sleep disorders of postmenopausal women in Iran. A randomized trial was conducted.

Methods: A total of 76 postmenopausal women were randomly assigned to either of the two groups: fennel-valerian extract or control. One 500 mg fennel-valerian extract capsule was given twice, daily for 8 weeks. The 500 mg oral placebo capsule (starch) was given the same way.

Results: The mean duration of hot flashes increased in both the groups over time (P < 0.001). The mean frequency and severity of hot flashes in the intervention group were significantly lower than in the control group, in the first and second months after intervention (P < 0.050). Women in the fennel-valerian extract group had a significantly lower Pittsburgh Sleep Quality Index score than the control group 2 months after intervention (P = 0.030).

Conclusions: This study found that fennel-valerian extract was effective for relieving sleep disorders as well as the severity and frequency of hot flashes compared with a placebo.

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茴香缬草提取物对绝经后妇女潮热和睡眠障碍的影响:一项随机试验。

目的:本研究旨在评估茴香和缬草提取物的混合物对伊朗绝经后妇女潮热和睡眠障碍的影响。进行了随机试验。方法:76名绝经后妇女随机分为两组:茴香缬草提取物组和对照组。给予茴香缬草提取物胶囊500 mg，每日2次，连用8周。500毫克口服安慰剂胶囊(淀粉)以同样的方式给予。结果:两组患者潮热的平均持续时间均随时间增加(P < 0.001)。干预组患者在干预后1、2个月出现潮热的平均频率和严重程度均显著低于对照组(P < 0.050)。干预2个月后，茴香缬草提取物组妇女的匹兹堡睡眠质量指数得分明显低于对照组(P = 0.030)。结论:本研究发现，与安慰剂相比，茴香缬草提取物对缓解睡眠障碍以及潮热的严重程度和频率有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Menopausal Medicine

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