An enlarged fetal thymus may be the initial response to intrauterine inflammation in pregnant women at risk for preterm birth.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Revista da Associacao Medica Brasileira Pub Date : 2023-01-01 DOI:10.1590/1806-9282.20221678

Tatiana Emy Nishimoto Kawanami Hamamoto, Alan Roberto Hatanaka, Marcelo Santucci França, Stéphanno Gomes Pereira Sarmento, Talita Micheletti Helfer, Roseli Mieko Yamamoto Nomura, Edward Araujo Júnior, Antonio Fernandes Moron

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Abstract

Objective: Fetal thymus involvement in prematurity has been studied, and this study aimed to evaluate its relationship with short cervix and amniotic fluid sludge in the second trimester of pregnancy.

Methods: In this prospective cross-sectional study, 79 pregnant women (19+0 to 24+6 weeks) were included, and cervical length and the presence or absence of amniotic fluid sludge were evaluated. In the three-vessel view of the fetal thorax, the thymus was identified, and its perimeter and transverse diameter were measured and transformed to a zeta score based on gestational age.

Results: Data from 22 women with short cervix (<25 mm) and 57 patients with normal cervix (≥25 mm) were analyzed. The transverse diameter of the fetal thymus was significantly greater in the short cervix group compared to that of the normal cervix group (z-score 2.708 vs. -0.043, p=0.003). There were no significant differences in the perimeter (z-score -0.039 vs. -0.071, p=0.890) or the transverse diameter (z-score 1.297 vs. -0.004, p=0.091) of the fetal thymus associated with the presence (n=21) or absence of sludge (n=58).

Conclusion: A short cervix is associated with an increased transverse diameter of the fetal thymus during the second trimester of gestation.

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胎儿胸腺肿大可能是有早产风险的孕妇对宫内炎症的最初反应。

目的:研究胎儿胸腺受累与早产的关系，探讨其与妊娠中期宫颈短缩及羊水淤积的关系。方法:在这项前瞻性横断面研究中，包括79名孕妇(19+0至24+6周)，并评估宫颈长度和羊水污泥的存在或不存在。在胎儿胸的三血管视图中，胸腺被识别，胸腺周长和横向直径被测量，并根据胎龄转化为zeta评分。结果:来自22名短子宫颈妇女的数据(结论:短子宫颈与妊娠中期胎儿胸腺横向直径增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista da Associacao Medica Brasileira 医学-医学：内科

CiteScore

2.20

自引率

0.00%

发文量

276

审稿时长

12 weeks

期刊介绍： A Revista da Associação Médica Brasileira (RAMB), editada pela Associação Médica Brasileira, desde 1954, tem por objetivo publicar artigos que contribuam para o conhecimento médico.