{"title":"Erythrodermic Psoriasis Successfully Treated with Anti IL-17: A Case Series.","authors":"Nicoletta Bernardini, Nevena Skroza, Ilaria Proietti, Alessandra Mambrin, Anna Marchesiello, Ersilia Tolino, Veronica Balduzzi, Concetta Potenza","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Erythrodermic psoriasis (EP) is a very rare but extremely severe subtype of chronic plaque psoriasis. Its pathogenesis still remains unknown, and current therapeutic strategies frequently end in failure. Erythrodermic psoriasis often requires hospitalization in order to control any kind of possible serious complications. Treatment of EP is a challenge for clinicians because international guidelines are lacking. Nevertheless, Th17 has been shown to be the second-most predominant T-cell type after Th2 in EP lesions. There is a growing body of evidence supporting the safety and efficacy of biologics in rapidly achieving near-total clearance of EP, particularly within the IL-17 class. Herein we report a series of 5 cases of EP successfully treated with anti-interleukines 17: Ixekizumab and Secukinumab.</p>","PeriodicalId":50903,"journal":{"name":"Acta Dermatovenerologica Croatica","volume":"29 4","pages":"191-195"},"PeriodicalIF":0.6000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Dermatovenerologica Croatica","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Erythrodermic psoriasis (EP) is a very rare but extremely severe subtype of chronic plaque psoriasis. Its pathogenesis still remains unknown, and current therapeutic strategies frequently end in failure. Erythrodermic psoriasis often requires hospitalization in order to control any kind of possible serious complications. Treatment of EP is a challenge for clinicians because international guidelines are lacking. Nevertheless, Th17 has been shown to be the second-most predominant T-cell type after Th2 in EP lesions. There is a growing body of evidence supporting the safety and efficacy of biologics in rapidly achieving near-total clearance of EP, particularly within the IL-17 class. Herein we report a series of 5 cases of EP successfully treated with anti-interleukines 17: Ixekizumab and Secukinumab.
期刊介绍：
Acta Dermatovenerologica Croatica (ADC) aims to provide dermatovenerologists with up-to-date information on all aspects of the diagnosis and management of skin and venereal diseases. Accepted articles regularly include original scientific articles, short scientific communications, clinical articles, case reports, reviews, reports, news and correspondence. ADC is guided by a distinguished, international editorial board and encourages approach to continuing medical education for dermatovenerologists.
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