{"title":"[Advances in the role of co-inhibitory receptors on T cell exhaustion in sepsis].","authors":"Q X Liu, M Xue, S Q Liu, Y Yang","doi":"10.3760/cma.j.cn112138-20221027-00794","DOIUrl":null,"url":null,"abstract":"脓毒症引起的免疫抑制与患者不良结局相关。T细胞耗竭是脓毒症免疫抑制的重要原因，表现为T细胞表面多种共抑制分子表达持续升高，T细胞增殖、活化及清除病原体的能力下降。脓毒症早期阻断共抑制分子介导的信号通路，可部分逆转T细胞耗竭，改善脓毒症免疫抑制状态。本文就共抑制分子在脓毒症T细胞耗竭中的研究进行综述，以期为脓毒症相关免疫抑制的靶向治疗提供依据。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 5","pages":"572-575"},"PeriodicalIF":0.0000,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua nei ke za zhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112138-20221027-00794","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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