John D Olson , Janet A Tooze , Daniel J Bourland , J Mark Cline , Eduardo B Faria , Eric P Cohen
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引用次数: 0
Abstract
Rationale and objectives
The accurate, non-invasive, and rapid measurement of renal cortical fibrosis is needed for well-defined benchmarks of permanent injury and for use of anti-fibrotic agents. It is also needed for non-invasive and rapid assessment of the chronicity of human renal diseases.
Materials and methods
We have used a non-human primate model of radiation nephropathy to develop a novel method of size-corrected CT imaging to quantify renal cortical fibrosis.
Results
Our method has an area under the receiver operating curve of 0.96, which is superior to any other non-invasive method of measuring renal fibrosis.
Conclusion
Our method is suitable for immediate translation to human clinical renal diseases.
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