Retired night shift workers exhibit poorer neurocognitive function compared to retired day workers.

IF 5.3 2区 医学 Q1 CLINICAL NEUROLOGY
Sleep Pub Date : 2023-11-08 DOI:10.1093/sleep/zsad098
Ashlyn Runk, H Matthew Lehrer, Meryl A Butters, Daniel J Buysse, Marissa A Evans, Robert T Krafty, Martica H Hall
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Abstract

Study objectives: Shift work is associated with compromised cognitive function, and with chronic exposure, may place shift workers at elevated risk for dementia. However, evidence of cognitive impairment among former night shift workers is mixed, possibly due to inconsistencies regarding retirement status, work history classification, and cognitive assessments. To address these limitations, this study compared neurocognitive function between retired night shift workers and retired day workers using a well-characterized sample and a rigorous neurocognitive test battery.

Methods: Participants (N = 61; mean age: 67.9 ± 4.7 years; 61% females; 13% non-white) were 31 retired day workers and 30 retired night shift workers equated on age, sex, race/ethnicity, premorbid IQ, years retired, and diary-assessed habitual sleep characteristics. Participants completed a neurocognitive battery assessing six cognitive domains (language, visuospatial ability, attention, immediate and delayed memory, executive function) and self-reported cognitive function. Linear regression models compared groups on individual cognitive domains, adjusting for age, sex, race/ethnicity, education level, and habitual sleep quality.

Results: Retired night shift workers scored lower than retired day workers on attention (B = -0.38, 95% CI [-0.75, -0.02], p = .040) and executive function (B = -0.55, 95% CI [-0.92, -0.17], p = .005). In post hoc analyses, attention and executive function were unrelated to diary-assessed habitual sleep characteristics (disruption, timing, and irregularity) in retired night shift workers.

Conclusions: The observed cognitive weaknesses in retired night shift workers may suggest increased risk for future dementia. Retired night shift workers should be followed to determine whether observed weaknesses progress.

与退休的白班工人相比,退休的夜班工人表现出更差的神经认知功能。
研究目标:轮班工作与认知功能受损有关,长期接触可能会使轮班工人患痴呆症的风险增加。然而,前夜班工人认知障碍的证据喜忧参半,可能是由于退休状态、工作史分类和认知评估不一致。为了解决这些局限性,本研究使用一个特征明确的样本和一个严格的神经认知测试组,比较了退休夜班工人和退休日工的神经认知功能。方法:参与者(N=61;平均年龄:67.9+/-4.7岁;61%为女性;13%为非白人)是31名退休的日工和30名退休的夜班工人,他们的年龄、性别、种族/民族、病前智商、退休年限和日记评估的习惯性睡眠特征相等。参与者完成了一个神经认知组,评估了6个认知领域(语言、视觉空间能力、注意力、即时记忆和延迟记忆、执行功能)和自我报告的认知功能。线性回归模型在个体认知领域对各组进行比较,并根据年龄、性别、种族/民族、教育水平和习惯性睡眠质量进行调整。结果:退休夜班工人在注意力(B=-0.38,95%CI[0.75,-0.02],p=0.040)和执行功能(B=-0.55,95%CI[0.92,-0.117],p=0.005)方面的得分低于退休白班工人。在事后分析中,退休夜班工人的注意力和执行功能与日记评估的习惯性睡眠特征(中断、时间安排、不规律)无关。结论:观察到的退休夜班工人的认知弱点可能表明未来患痴呆症的风险增加。应跟踪退休夜班工人,以确定观察到的薄弱环节是否进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sleep
Sleep 医学-临床神经学
CiteScore
10.10
自引率
10.70%
发文量
1134
审稿时长
3 months
期刊介绍: SLEEP® publishes findings from studies conducted at any level of analysis, including: Genes Molecules Cells Physiology Neural systems and circuits Behavior and cognition Self-report SLEEP® publishes articles that use a wide variety of scientific approaches and address a broad range of topics. These may include, but are not limited to: Basic and neuroscience studies of sleep and circadian mechanisms In vitro and animal models of sleep, circadian rhythms, and human disorders Pre-clinical human investigations, including the measurement and manipulation of sleep and circadian rhythms Studies in clinical or population samples. These may address factors influencing sleep and circadian rhythms (e.g., development and aging, and social and environmental influences) and relationships between sleep, circadian rhythms, health, and disease Clinical trials, epidemiology studies, implementation, and dissemination research.
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