wnt11f2 Zebrafish, an Animal Model for Development and New Insights in Bone Formation.

IF 1.4 4区生物学 Q4 DEVELOPMENTAL BIOLOGY

Zebrafish Pub Date : 2023-02-01 DOI:10.1089/zeb.2022.0042

Caroline Caetano da Silva, Agnes Ostertag, Ratish Raman, Marc Muller, Martine Cohen-Solal, Corinne Collet

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引用次数: 0

Abstract

Wnt signaling is a key regulator of osteoblast differentiation and mineralization in humans and animals, mediated by the canonical Wnt/β-catenin and noncanonical signaling pathways. Both pathways are crucial in regulating osteoblastogenesis and bone formation. The zebrafish silberblick (slb) carries a mutation in wnt11f2, a gene that contributes to embryonic morphogenesis; however, its role in bone morphology is unknown. wnt11f2 was originally known as wnt11; it was recently reclassified to avoid confusion in comparative genetics and disease modeling. The goal of this review is to summarize the characterization of the wnt11f2 zebrafish mutant and to deliver some new insights concerning its role in skeletal development. In addition to the previously described defects in early development in this mutant as well as craniofacial dysmorphia, we show an increase in tissue mineral density in the heterozygous mutant that points to a possible role of wnt11f2 in high bone mass phenotypes.

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wnt11f2斑马鱼:发育的动物模型和骨形成的新见解。

Wnt信号是人类和动物成骨细胞分化和矿化的关键调节因子，由典型的Wnt/β-catenin和非典型的信号通路介导。这两种途径在调节成骨细胞发生和骨形成中都是至关重要的。斑马鱼silberblick (slb)携带wnt11f2基因突变，该基因有助于胚胎形态发生;然而，其在骨形态中的作用尚不清楚。Wnt11f2最初被称为wnt11;它最近被重新分类，以避免在比较遗传学和疾病模型中混淆。本文的目的是总结wnt11f2斑马鱼突变体的特征，并就其在骨骼发育中的作用提供一些新的见解。除了先前描述的该突变体早期发育缺陷以及颅面畸形外，我们还发现杂合突变体的组织矿物质密度增加，这表明wnt11f2可能在高骨量表型中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zebrafish DEVELOPMENTAL BIOLOGY-ZOOLOGY

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

3 months

期刊介绍： Zebrafish is the only peer-reviewed journal dedicated to the central role of zebrafish and other aquarium species as models for the study of vertebrate development, evolution, toxicology, and human disease. Due to its prolific reproduction and the external development of the transparent embryo, the zebrafish is a prime model for genetic and developmental studies. While genetically more distant from humans, the vertebrate zebrafish nevertheless has comparable organs and tissues, such as heart, kidney, pancreas, bones, and cartilage. Zebrafish introduced the new section TechnoFish, which highlights these innovations for the general zebrafish community. TechnoFish features two types of articles: TechnoFish Previews: Important, generally useful technical advances or valuable transgenic lines TechnoFish Methods: Brief descriptions of new methods, reagents, or transgenic lines that will be of widespread use in the zebrafish community Zebrafish coverage includes: Comparative genomics and evolution Molecular/cellular mechanisms of cell growth Genetic analysis of embryogenesis and disease Toxicological and infectious disease models Models for neurological disorders and aging New methods, tools, and experimental approaches Zebrafish also includes research with other aquarium species such as medaka, Fugu, and Xiphophorus.